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2010, vol. 63, br. 1-2, str. 82-85
Medikamentozni tretman aortne stenoze - uloga statina i inhibitora angiotenzin-konverujućeg enzima
Vojnomedicinska akademija, Klinika za kardiologiju, Beograd

e-adresazak71@eunet.rs
Ključne reči: Aortna stenoza + medikamentozni tretman; Statini; ACE inhibitori; Ateroskleroza
Sažetak
Aortna stenoza je najčešća valvularna bolest srca. Aortna skleroza je prva karakteristična lezija kuspisa i danas se smatra procesom identičnim aterosklerozi, dok uznapredovalu fazu bolesti karakteriše proces mineralizacijem, formiranje koštanog matriksa i kalcifikacija kuspisa pod uticajem inflamatornih ćelija i osteopontina. Razvoj kliničke slike je postepen. Bolest može dugo da bude asimptomatska, čak i u prisustvu teške aortne stenoze. Nastanak simptoma je povezan sa lošim ishodom bolesti, bez obzira na težinu aortne stenoze. Do sada nisu bili poznati medikamenti koji prolongiraju ili zaustavljaju proces aortne stenoze. Sličnost rane faze procesa aortne stenoze i ateroskleroze dovela je do podsticaja za primenu medikamenata kao što su statini i inhibitori angiotenzin-konvertujućeg enzima i u aortnoj stenozi, s obzirom na ispoljen pozivan efekat na proces ateroskleroze. Prvi rezultati istraživanja primene statina i inhibitora angiotenzin-konvertujućeg enzima u aortnoj stenozi su ohrabrujući, ali još uvek nisu dostupni rezultati velikih studija.
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O članku

jezik rada: srpski
vrsta rada: pregledni članak
DOI: 10.2298/MPNS1002082D
objavljen u SCIndeksu: 24.08.2010.

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