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2008, vol. 61, br. 9-10, str. 512-516
Hemodinamički efekti intravenske primene ACE-inhibitora u prevenciji srčane insuficijencije posle hirurške revaskularizacije miokarda
Univerzitet u Beogradu, Medicinski fakultet, Institut za kardiovaskularne bolesti 'Dedinje'

e-adresaflorijan@yubc.net
Ključne reči: ACE inhibitori; Srčana insuficijencija; Miokardna revaskularizacija; Hemodinamika
Sažetak
Analizirali smo hemodinamičke efekte intravenske primene inhibitora angiotenzin-konvertujućeg enzima quinaprilata i poredili smo ih sa hemodinamičkim efektima standardne inotropno-vazodilatatorne terapije dopaminom i natrijum-nitroprusidom. Analizom je obuhvaćeno 30 pacijenata podvrgnutih hirurškoj revaskularizaciji miokarda uz primenu kardiopulmonalnog bajpasa sa lošom funkcijom leve komore (ejekciona frakcija <30%). Kontrolnu grupu je činilo 40 pacijenata sa istom medicinskom problematikom. Svi ispitanici su imali plasiran kompletan invazivni hemodinamički monitoring, a lekovi su aplicirani preko infuzionih pumpi. Utvrdili smo značajno povećanje minutnog volumena srca, srčanog indeksa, indeksa udarnog rada leve komore, redukciju sistolnog arterijskog pritiska kao i redukciju plućne vaskularne rezistencije, dok nije bilo razlike u vrednostima sistemske vaskularne rezistencije i mešane venske saturacije u odnosu na kontrolnu grupu. Došli smo do zaključka da je intravenska primena quinaprilata (doza 0,5 mg/sat) terapija izbora u postoperativnom lečenje pacijenata sa lošom funkcijom leve komore (ejekciona frakcija <30%).
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O članku

jezik rada: srpski
vrsta rada: stručni članak
DOI: 10.2298/MPNS0810512L
objavljen u SCIndeksu: 09.02.2009.

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