Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:23
  • preuzimanja u poslednjih 30 dana:11

Sadržaj

članak: 5 od 34  
Back povratak na rezultate
Arhiv za farmaciju
2019, vol. 69, br. 2, str. 67-79
Antifungalna aktivnost etarskog ulja Seseli rigidum Waldst. & Kit. (Apiaceae) na rast izolata Candida albicans
Marčetić Mirjana D.a ORCID, Božić Dragana D.b ORCID, Milenković Marina T.b ORCID, Kovačević Mirjana M.c, Kovačević Nada N.a ORCID
aUniverzitet u Beogradu, Farmaceutski fakultet, Institut za farmakognoziju, Srbija
bUniverzitet u Beogradu, Farmaceutski fakultet, Institut za mikrobiologiju i imunologiju, Srbija
cPoliklinika Beo-lab plus, Beograd

e-adresa: mirjana.marcetic@pharmacy.bg.ac.rs
Projekat:
Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (MPNTR - 173021)

Ključne reči: antifungalna aktivnost; Seseli rigidum; etarsko ulje; Candida albicans
Sažetak
Ispitivano je delovanje etarskih ulja korena, herbe i ploda devesilja, Seseli rigidum iz dve prirodne populacije na 28 izolata Candida albicans i jedan standardni soj C. albicans ATCC 10259. Sojevi C. albicans koji su korišćeni u ovom ispitivanju izolovani su iz orofaringealnog brisa, vaginalnog i/ili cervikalnog brisa, brisa oka, brisa rane, fecesa i urina. Ispitivani sojevi su pokazali visok stepen rezistencije prema delovanju kontrolnog antimikotika flukonazola, a u nešto manjoj meri i amfotericina B. Etarska ulja devesilja, primenjena u koncentracijama 50-200 mg/ml, uzrokovala su inhibiciju rasta ispitivanih sojeva (28,6-46,4% testiranih sojeva). Inhibitorni efekat na tri soja C. albicans ostvaren je sa etarskim uljem korena, sa oba lokaliteta, već pri koncentraciji od 50 mg/ml. Dominantno jedinjenje u ovim etarskim uljima je predstavljao falkarinol (57,5% i 88,8%). Slabiju aktivnost su ispoljila etarska ulje herbe i ploda devesilja, koja su u koncentraciji od 100 mg/ml inhibirala rast pojedinih ispitivanih sojeva. Kod etarskog ulja ploda uočeno je nešto izraženije delovanje etarskog ulja populacije iz Brđanske klisure, koje je sadržalo veću količinu a-pinena i b-felandrena, a manju količinu sabinena. Dobijeni rezultati su pokazali da etarska ulja korena, herbe i ploda devesilja ispoljavaju značajnu antifungalnu aktivnost na pojedine rezistentne sojeve C. albicans.
Reference

Abbaskhan, A., Choudhary, M.I., Ghayur, M.N., Parween, Z., Shaheen, F., Gilani, A.U., i dr. (2012) Biological activities of Indian celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh. Phytother Res., 26: 783-789

Arendrup, M.C., Patterson, T.F. (2017) Multidrug-resistant Candida: Epidemiology, molecular mechanisms, and treatment. Journal of Infectious Diseases, 15:216(suppl_3): S445-S451

Ball, P.W. (1968) Seseli L. u: Tutin T.G; Heywood V.H; Burges N.A; Moore D.M; Valentine D.H; Walters S.M; Webb D.A. [ur.] Flora Europaea, London: Cambridge University Press, Vol. III, p. 334-338

Barrero, A.F., Herrador, M. M., Arteaga, P. (1994) Sesquiterpene lactones and other constituents of Seseli vayredanum. Phytochemistry, 37(5): 1351-1358

1

Christensen, L.P. (2011) Aliphatic c17-polyacetylenes of the falcarinol type as potential health promoting compounds in food plants of the Apiaceae family. Recent Patents on Food, Nutrition & Agriculturee, 3(1): 64-77

Christensen, L.P., Brandt, K. (2006) Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis. Journal of Pharmaceutical and Biomedical Analysis, 41(3): 683-693

Clinical and Laboratory Standards Institute (CLSI) (2017) Performance standards for antimicrobial susceptibility testing. document M100-S17, ISBN 1-56238-625-5

36

Council of Europe (2016) European pharmacopoeia. Strasbourg

Dignani, M.C. (2009) Candida. u: Annaisie E.J; McGinnis M.R; Pfaller M.A. [ur.] Clinical mycology, New York: Churchill Livingstone

2

Duarte, M.C.T., Figueira, G.M., Sartoratto, A., Rehder, V.L.G., Delarmelina, C. (2005) Anti-Candida activity of Brazilian medicinal plants. Journal of Ethnopharmacology, 97(2): 305-311

Enoch, D.A., Yang, H., Aliyu, S.H., Micallef, C. (2017) The changing epidemiology of invasive fungal infections. u: Lion T. [ur.] Methods mol biol: Human fungal pathogen identification: Methods and protocols, New York: Humana Press, vol 1508

Gonçalves, M.J., Tavares, A.C., Cavaleiro, C., Cruz, M.T., Lopes, M.C., Canhoto, J., Salgueiro, L. (2012) Composition, antifungal activity and cytotoxicity of the essential oils of Seseli tortuosum L. and Seseli montanum subsp. peixotoanum (Samp.) M. Laínz from Portugal. Industrial Crops and Products, 39: 204-209

Gudlaugsson, O., Gillespie, S., Lee, K., Vandle, B.J., Hu, J., Messer, S., Herwaldt, L., Pfaller, M., Diekema, D. (2003) Attributable mortality of nosocomial candidemia, revisited. Clinical Infectious Diseases, 37(9): 1172-1177

Horn, D.L., Neofytos, D., Anaissie, E.J., Fishman, J.A., Steinbach, W.J., Olyaei, A.J., Marr, K.A., Pfaller, M.A., Chang, C., Webster, K.M. (2009) Clinical characteristics of 2019 patients with candidemia: Data from PATH Alliance Registry. Clin Infect Dis, 48: 1695-1703

4

Hyldgaard, M., Mygind, T., Meyer, R.L. (2012) Essential oils in food preservation: Mode of action, synergies, and interactions with food matrix components. Frontiers in Microbiology, 3: 1-14

Küpeli, E., Tosun, A., Yesilada, E. (2006) Anti-inflammatory and antinociceptive activities of Seseli L. species (Apiaceae) growing in Turkey. Journal of Ethnopharmacology, 104(3): 310-314

Ma, X.H., Zheng, C.J., Han, L.Y., Xie, B., Jia, J., Cao, Z.W., Li, Y.X., Chen, Y.Z. (2009) Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discovery Today, 14(11-12): 579-588

Marčetić, D. M., Lakušić, S. B., Lakušić, V. D., Kovačević, N.N. (2013) Variability of the root essential oils of Seseli rigidum Waldst. & Kit. (Apiaceae) from different populations in Serbia. Chemistry & Biodiversity, 10(9): 1653-1666

1

Marčetić, M., Božić, D., Milenković, M., Lakušić, B., Kovačević, N. (2012) Chemical composition and antimicrobial activity of essential oil of different parts of Seseli rigidum. Natural Product Communications, 7(8): 1091-4

Milosavljević, S.M., Tešević, V.V., Vučković, I.M., Jadranin, M.B., Vajs, V.E., Soković, M.D., Janaćković, P.T., Jovanović, A. (2007) Composition and antifungal activity of the essential oil of Seseli annuum wild-growing in Serbia. Fitoterapia, 78(4): 319-322

Murray, P., Rosenthal, K., Pfaller, M. (2013) Medical microbiology. Philadelphia: Elsevier Inc - Saunders, p. 605-83

Nikolić, V. (1973) Apiaceae - rod Seseli L. u: Josifović M. [ur.] Flora SR Srbije, Beograd: Srpska akademija nauka i umetnosti, Vol. V

1

Pfaller, M.A., Diekema, D.J. (2007) Epidemiology of invasive candidiasis: A persistent public health problem. Clinical Microbiology Reviews, 20(1): 133-163

Schinkovitz, A., Stavri, M., Gibbons, S., Bucar, F. (2008) Antimycobacterial polyacetylenes from Levisticum officinale. Phytotherapy Research, 22(5): 681-684

Shahabipour, S., Javidnia, K., Firuzi, O., Miri, R. (2012) Chemical constituents and cytotoxic activity of the essential oil of Libanotis transcaucasica Schischk from Iran. Res Pharm Sci, 7(5): S745

Silva, F., Ferreira, S., Duarte, A., Mendonça, D.I., Domingues, F.C. (2011) Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B. Phytomedicine, 19(1): 42-47

Skalicka-Wozniak, K., Los, R., Glowniak, K., Malm, A. (2010) Comparison of hydrodistillation and headspace solid-phase microextraction techniques for antibacterial volatile compounds from the fruits of Seseli libanotis. Natural Product Communications, 5(9): 1427-30

1

Stojkovic, S., Petrovic, S., Kukic, J., Dzamic, A., Ristic, M., Milenkovic, M., Glamoclija, J., Sokovic, M., Stojkovic, D. (2009) Chemical composition and antimicrobial and antioxidant activity of Seseli rigidum flower essential oil. Chemistry of Natural Compounds, 45(2): 253-256

Tosun, A., Özkal, N., Yildiz, S. (2004) Antimicrobial activity screening of some Seseli L. species growing in Turkey. J. Fac. Pharm, Ankara, 33(3):151-5

Tosun, A., Akkol, E.K., Yeşilada, E. (2009) Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae). Zeitschrift für Naturforschung C, 64(1-2): 56-62

Vučković, I.M., Trajković, V.S., Macura, S., Tešević, V.V., Janaćković, P.T., Milosavljević, S.M. (2007) A novel cytotoxic lignan from Seseli annuum L. Phytotherapy Research, 21(8): 790-792

Wagner, H. (2011) Synergy research: Approaching a new generation of phytopharmaceuticals. Fitoterapia, 82(1): 34-37

Živković, L., Čabarkapa, A., Marčetić, M., Kovačević, N., Bajić, V., Jovičić, S., Spremo-Potparević, B. (2016) Evaluation of genotoxic and antigenotoxic properties of essential oils of Seseli rigidum Waldst. & Kit. (Apiaceae). Arch. Biol. Sci., Belgrade, 68(1):135-44
   

O članku

jezik rada: srpski
vrsta rada: izvorni naučni članak
DOI: 10.5937/arhfarm1902067X
objavljen u SCIndeksu: 02.03.2020.
Creative Commons License 4.0

Povezani članci

Nema povezanih članaka