Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:7
  • preuzimanja u poslednjih 30 dana:0

Sadržaj

članak: 10 od 84  
Back povratak na rezultate
Medicinski pregled
2018, vol. 71, br. 9-10, str. 301-208
Udruženost infekcije humanim papiloma virusom i abnormalnosti skvamoznih ćelija grlića materice
Dabeski Drage
University Clinic of Gynecology and Obstetrics, Medical Faculty, Skopje, Republic of Macedonia

e-adresa: drdabeski@yahoo.com
Ključne reči: papiloma virusne infekcije; displazija grlića materice; skvamozne intraepitelijalne lezije grlića materice; PCR; HPV-DNK testiranje; kolposkopija
Sažetak
Uvod. Cilj studije bio je da se potvrdi postojanje udruženosti između infekcije humanim papiloma virusom i abnormalnosti skvamoznih ćelija grlića materice. Materijal i metode. Studija preseka, sprovedena u periodu od januara 2016. do juna 2017. godine na 128 seksualno aktivnih žena, starosti od 20 do 59 godina, sa abnormalnostima skvamoznih ćelija na cervikalnoj citologiji, koje su došle na godišnji ginekološki pregled na Univerzitetsku kliniku za ginekologiju i akušerstvo u Skoplju. Kod svih žena je urađeno testiranje infekcije humanim papiloma virusom i kolposkopska biopsija grlića materice sa endocervikalnom kiretažom za histopatološku analizu. Rezultati. Analiza podataka pokazala je povećanje prisustva infekcije humanim papiloma virusom paralelno sa povećanjem citopatološkog (p = 0.029296) i histopatološkog (p = 0.029443) stepena lezije grlića materice. Analiza podataka pokazala je udruženost između onkogenog potencijala virusa i citopatološkog (p = 0.000086) i histopatološkog (p = 0.0001) stepena lezije grlića materice. Infekcija humanim papiloma virusom otkrivena je kod 75% ispitanih žena. Odnos između prevalencije visokorizičnih i niskorizičnih genotipova humanih papiloma virusa iznosio je 56,25 : 10,94%. Mešovita infekcija humanim papiloma virusom otkrivena je kod 32,03% od svih žena, odnosno 42,71% kod žena pozitivnih na humani papiloma virus. Najčešći genotipovi infekcije humanim papiloma virusom u opadajućem redosledu bili su: humani papiloma virus-16 (43,75%), humani papiloma virus-31 (15,62%), humani papiloma virus-18 (10,4%), humani papiloma virus-45 (9,37%), humani papiloma virus-33 (7,29%) itd. Zaključak. Postoji udruženost između infekcije humanim papiloma virusom i abnormalnosti skvamoznih ćelija grlića materice. Žene mlađe od 30 godina bile su najugroženija starosna grupa.
Reference

1

Agodi, A., Barchitta, M., La, R.N., Cipresso, R., Guarnaccia, M., Caruso, M., Castiglione, M.G., Ettore, G., Travali, S. (2009) Human Papillomavirus Infection: Low-Risk and High-Risk Genotypes in Women in Catania, Sicily. International Journal of Gynecologic Cancer, 19(6): 1094-1098

1

Andonovska, J. (2014) Genotypic distribution and prevalence of the HPV infection in Macedonia. International Journal of Infectious Diseases, 21: 398

1

Bosch, F.X., Lorincz, A., Munoz, N., Meijer, C.J.L.M., Shah, K.V. (2002) The causal relation between human papillomavirus and cervical cancer. Journal of Clinical Pathology, 55(4): 244-265

Brink, A.A. T. P., Snijders, P.J. F., Meijer, C.J. L. M. (2007) HPV Detection Methods. Disease Markers, 23(4): 273-281

Cuschieri, K.S., Cubie, H.A., Whitley, M.W., Seagar, A.L., Arends, M.J., Moore, C., i dr. (2004) Multiple high risk HPV infections are common in cervical neoplasia and young women in a cervical screening population. J Clin Pathol, 57(1): 68-72

3

Cuzick, J., Clavel, C., Petry, K., Meijer, C.J.L.M., Hoyer, H., Ratnam, S., Szarewski, A., Birembaut, P., Kulasingam, S., Sasieni, P., Iftner, T. (2006) Overview of the European and North American studies on HPV testing in primary cervical cancer screening. International Journal of Cancer, 119(5): 1095-1101

1

de Villiers, E., Fauquet, C., Broker, T.R., Bernard, H., zur Hausen, H. (2004) Classification of papillomaviruses. Virology, 324(1): 17-27

Duvlis, S. (2000) Genotipizacija na human papiloma virus (HPV) kaj ženskata populacija vo Republika Makedonija. Skopje: Univerzitet Sv. Kiril i Metodij, [magisterski trud]

Evans, M.F., Adamson, C.S.-C., Papillo, J.L., St. John, T.L., Leiman, G., Cooper, K. (2006) Distribution of human papillomavirus types in ThinPrep Papanicolaou tests classified according to the Bethesda 2001 terminology and correlations with patient age and biopsy outcomes. Cancer, 106(5): 1054-1064

Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Mathers, C., i dr. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 136(5): 359-86

Franco, E. L. (2003) Chapter 13: Primary Screening of Cervical Cancer With Human Papillomavirus Tests. JNCI Monographs, 2003(31): 89-96

1

García-García, J.A., Pérez-Vallés, A., Martorell, M., Gómez, B., Gómez-Cabrero, D., Soler, F., Calabuig, C. (2010) Distribution of Human Papillomavirus Types in Women from Valencia, Spain, with Abnormal Cytology. Acta Cytologica, 54(2): 159-164

2

Grozdanov, P., Zlatkov, V., Ganchev, G., Karagiosov, I., Toncheva, D., Galabov, A.S. (2014) HPV prevalence and type distribution in women with normal or abnormal Pap smear in Bulgaria. Journal of Medical Virology, 86(11): 1905-1910

Hariri, S., Unger, E. R., Powell, S. E., Bauer, H. M., Bennett, N. M., Bloch, K. C., Niccolai, L. M., Schafer, S., Steinau, M., Markowitz, L. E. (2012) Human Papillomavirus Genotypes in High-Grade Cervical Lesions in the United States. Journal of Infectious Diseases, 206(12): 1878-1886

Herrington, C.S., Baak, J.P.A., Mutter, L. (2014) Cervical squamous intraepithelial lesions. u: Mutter G.L., Prat J. [ur.] Pathology of the female reproductive tract, Philadelphia: Elsevier, p. 200-31; 3rd ed

2

Kovachev, S., Slavov, V., Slavova, K. (2013) Prevalence of human papillomavirus infection in women in some cities and regions of Bulgaria. Journal of Medical Virology, 85(9): 1577-1584

Kovačević, G., Jovanović-Galović, A., Petrović, V., Vinarž, Ž., Marinković, G., Brašanac, B., Milošević, V. (2016) Učestalost infekcije humanim papiloma virusom kod studentkinja u Novom Sadu u Srbiji. Srpski arhiv za celokupno lekarstvo, vol. 144, br. 5-6, str. 300-306

Kurman, R.J., Carcangiu, M.L., Herrington, C.S., Young, R.H., ur. (2014) World Health Organization classification of tumors of female reproductive organs. Lyon: IARC Press, 4th ed

1

Lau, S., Franco, E.L. (2005) Management of low-grade cervical lesions in young women. Canadian Medical Association Journal, 173(7): 771-774

1

Mazarico, E., Gonzalez-Bosquet, E. (2012) Prevalence of infection by different genotypes of human papillomavirus in women with cervical pathology. Gynecologic Oncology, 125(1): 181-185

2

Moga, M.A., Irimie, M., Oanta, A., Pascu, A., Burtea, V. (2014) Type-specific Prevalence of Human Papillomavirus by Cervical Cytology among Women in Brasov, Romania. Asian Pacific Journal of Cancer Prevention, 15(16): 6887-6892

1

Pista, A., de Oliveira, C.F., Lopes, C., Cunha, M.J. (2013) Human Papillomavirus Type Distribution in Cervical Intraepithelial Neoplasia Grade 2/3 and Cervical Cancer in Portugal: A CLEOPATRE II Study. International Journal of Gynecologic Cancer, 23(3): 500-506

1

Sandri, M.T., Riggio, D., Salvatici, M., Passerini, R., Zorzino, L., Boveri, S., Radice, D., Spolti, N., Sideri, M. (2009) Typing of human papillomavirus in women with cervical lesions: Prevalence and distribution of different genotypes. Journal of Medical Virology, 81(2): 271-277

Scott, M. (2016) The pathology of cervical cancer. u: Ayhan A., Reed N., Gulterin M., Dursun P. [ur.] Textbook of gynaecological oncology, Ankara: Gunes Publishing, p. 376-80; 3rd ed

Solomon, D. (2002) The 2001 Bethesda SystemTerminology for Reporting Results of Cervical Cytology. JAMA, 287(16): 2114

Stewart, B.W., Wild, C.P., ur. (2014) World cancer report. u: Encyclopedia of Toxicology, Lyon: International Agency for Research on Cancer

Stojanovska, V., Panov, S., Bašeska, N., Josifovska, S., Dimitrov, G., Petanovski, Z., i dr. (2009) Prevalencija i distribucija na human papilloma virus infekcija kaj klinički suspektni cervikalni lezii. Makedon Med Pregl, 63(1): 17-24

1

Vieira, L., Almeida, A. (2013) The cytology and DNA detection by the PapilloCheck® test in the diagnosis of human papillomavirus infection. European Journal of Microbiology and Immunology, 3(1): 61-67

Vrtacnik-Bokal, E., Rakar, S., Mozina, A., Poljak, M. (2005) Human papillomavirus in relation to mild dyskaryosis in conventional cervical cytology. Eur J Gynaecol Oncol, 26(1): 39-42

2

Vujošević, D., Vuksanović, V., Poljak, M., Jokmanović, N. (2012) Human Papillomavirus Genotype Spectrum in Studied Group of Montenegrin Women. Acta Medica (Hradec Kralove, Czech Republic), 55(3): 130-132

Zerat, L. (2002) La nouvelle terminologie de Bethesda: quels changements?. La Revue du Praticien Gynécologie et Obstétrique, (Special No):3-10

2

Zur, H.H. (1976) Condylomata acuminata and human genital cancer. Cancer Res, 36(2 Pt 2), 794

6

zur Hausen, H. (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nature Reviews Cancer, 2(5): 342-350
   

O članku

jezik rada: engleski
vrsta rada: stručni članak
DOI: 10.2298/MPNS1810301D
objavljen u SCIndeksu: 20.05.2019.

Povezani članci

Nema povezanih članaka