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Acta medica Medianae
2023, vol. 62, iss. 1, pp. 27-35
Risk factors for the development of gastric cancer: A single center experience
Rančić Andrijaa, Brzački Vesnab, Popović Aleksandarc, Topalović Marijad
aClinical Centre Niš, Clinic of Gastroenterology and Hepatology, Serbia
bClinical Centre Niš, Clinic of Gastroenterology and Hepatology, Serbia + Univeristy of Niš, Faculty of Medicine, Serbia
cClinical Centre Niš, Clinic of Oncology, Serbia
dClinical Centre Niš, Clinic for Lung Diseases, Serbia

email: andrija.m.rancic@gmail.com
Abstract
Gastric cancer is the fourth most common cancer in the world with over a million new cases per year, and over 750,000 deaths caused by it. The highest incidence is recorded in Japan and China, Eastern Europe and South America, and the lowest is in Africa. The disease is 2 to 3 times more common within male population and people over 60 years of age, but this boundary shifts towards younger age. Five-year survival rate in European countries is 10 to 30%. This is a multifactorial disease and the most important risk factors are: Helicobacter pylori infection, smoking cigarettes, alcohol consumption, male gender, older age, reduced intake of vegetables and fruits, genetic predisposition, diabetes mellitus, etc. A prospective study was conducted on a selected population of 43 patients diagnosed with the two most common types of stomach cancer: adenocarcinoma and signet ring cell type cancer. Out of the total number of examinees, there were 32 male and 11 female patients, the average age of 68.83±9.26. Among all patients, 39.5% were smokers, 20.9% were alcohol consumers, 62.8% had Helicobacter pylori infection and 16.3% patients had diabetes mellitus. Analysis of the relationship between sex, age, smoking, alcohol intake and diabetes mellitus with the type of cancer did not show statistical significance. The frequency of Helicobacter pylori was statistically significantly different in relation to the type of cancer (p=0.007). In our study, there was no statistically significant difference between the male gender, the younger population, smokers, chronic alcohol consumers, and patients with diabetes mellitus and a certain type of cancer. Helicobacter pylori infection was found to be a key factor in the development of both types of gastric cancer. This research included a smaller sample of patients and it is necessary to examine a larger number of subjects in the future.
References

*** (2018) WHO Global status report on alcohol and health 2018. Geneva

*** (2010) WHO Classification of tumours of the digestive system. Lyon: IARC, 4th ed

1

Ang, T.L., Fock, K.M. (2014) Clinical epidemiology of gastric cancer. Singap Med J, 55(12): 621-8

Arnold, M., Park, J.Y., Camargo, M.C., Lunet, N., Forman, D., Soerjomataram (2020) Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035. Gut, 69(5): 823-9

Camargo, M.C., Kim, W-H., Chiaravalli, A.M., Kim, K-M., Corvalan, A.H., Matsuo, K., et al. (2014) Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis. Gut, 63(2): 236-43

Cheng, X.J., Lin, J.C., Tu, S.P. (2016) Etiology and prevention of gastric cancer. Gastrointest Tumors, 3(1): 25-36

Chiba, T., Marusawa, H., Seno, H., Watanabe, N. (2008) Mechanism for gastric cancer development by Helicobacter pylori infection. J Gastroenterol Hepatol, 23: 1175-81

Dabo, B., Pelucchi, C., Rota, M., Jain, H., Bertuccio, P., Bonzi, R., et al. (2022) The association between diabetes and gastric cancer: results from the Stomach cancer pooling project consortium. Eur J Cancer Prev, 31(3): 260-9

Dandona, P., Thusu, K., Cook, S., Snyder, B., Makowski, J., Armstrong, D., et al. (1996) Oxidative damage to DNA in diabetes mellitus. Lancet, 347 (8999): 444-5

Duell, E.J., Travier, N., Lujan-Barroso, L., Clavel-Chapelon, F., Boutron-Ruault, M-C., Morois, S., et al. (2011) Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 94(5): 1266-75

Engel, L.S., Chow, W-H., Vaughan, T.L., Gammon, M.D., Risch, H.A., Stanford, J.L., et al. (2003) Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst, 95(18): 1404-13

Farrow, D.C., Vaughan, T.L., Sweeney, C., Gammon, M.D., Chow, W.H., Risch, H.A., et al. (2000) Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes Control, 11(3): 231-8

Felipe, A.V., Silva, T.D., Pimenta, C.A., Kassab, P., Forones, N.M. (2012) lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a Brazilian population. Biol Res, 45(4): 369-74

2

Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., Parkin, D.M. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127(12): 2893-917

Ford, A.C., Forman, D., Hunt, R.H., Yuan, Y., Moayyedi, P. (2014) Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials. BMJ, 348: g3174

Hoyo, C., Cook, M.B., Kamangar, F., Freedman, N.D., Whiteman, D.C., Bernstein, L., et al. (2012) Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol, 41(6): 1706-18

2

Hu, B., El, H.N., Sittler, S., Lammert, N., Barnes, R., Meloni-Ehrig, A. (2012) Gastric cancer: Classification, histology and application of molecular pathology. J Gastrointest Oncol, 3(3): 251-61

Ikeda, F., Doi, Y., Yonemoto, K., Ninomiya, T., Kubo, M., Shikata, K., et al. (2009) Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection: a population-based cohort study. Gastroenterology, 136(4): 1234-41

Inoue, M., Iwasaki, M., Otani, T., Sasazuki, S., Noda, M., Tsugane, S. (2006) Diabetes mellitus and the risk of cancer: results from a largescale population-based cohort study in Japan. Arch Intern Med, 166(17): 1871-7

Ishaq, S., Nunn, L. (2015) Helicobacter pylori and gastric cancer: A state of the art review. Gastroenterol Hepatol Bed Bench, 8: S6-S14

Jarl, J., Heckley, G., Brummer, J., Gerdtham, U.G. (2013) Time characteristics of the effect of alcohol cessation on the risk of stomach cancer: a meta-analysis. BMC Public Health, 13: 600

Jee, S.H., Ohrr, H., Sull, J.W., Yun, J.E., Ji, M., Samet, J.M. (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA, 293(2): 194-202

2

Jemal, A., Center, M.M., Desantis, C., Ward, E.M. (2010) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomark Prev, 19(8): 1893-1907

2

Karimi, P., Islami, F., Anandasabapathy, S., Freedman, N.D., Kamangar, F. (2014) Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev, 23(5): 700-13

Ladeiras-Lopes, R., Pereira, A.K., Nogueira, A., Pinheiro-Torres, T., Pinto, I., Santos-Pereira, R., et al. (2008) Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control, 19(7): 689-701

Lauren, P. (1965) The two histological main types of gastric carcinoma: Diffuse and so-called intestinaltype carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand, 64: 31-49

Lauwers, G.Y., Mullen, J.T., Schreiber, K.E.C., Chung, D.C. (2014) Familial Gastric Cancers. Pathol Case Rev, 19: 66-73

Lindblad, M., Rodriguez, L.A.G., Lagergren, J. (2005) Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control, 16(3): 285-294

Lizasa, H., Nanbo, A., Nishikawa, J., Jinushi, M., Yoshiyama, H. (2012) Epstein-Barr Virus (EBV)-associated Gastric Carcinoma. Viruses, 4(12): 3420-39

Ma, J.L., Zhang, L., Brown, L.M., Li, J-Y., Shen, L., Pan, K-F., et al. (2012) Fifteen year effects of Helicobacter pylori, garlic and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst, 104(6): 488-92

Ma, K., Baloch, Z., He, T-T., Xia, X. (2017) Alcohol consumption and gastric cancer risk: A meta-analysis. Med Sci Monit, 23: 238-46

Malfertheiner, P., Megraud, F., Rokkas, T., Gisbert, J.P., Liou, J-M., Schulz, C., et al. (2022) Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut, 2022: gutjnl-2022-327745

Moy, K.A., Fan, Y., Wang, R., Gao, Y-T., Yu, M.C., Yuan, J-M. (2010) Alcohol and tobacco use in relation to gastric cancer: A prospective study of men in Shanghai, China. Cancer Epidemiol Biomark Prev, 19(9): 2287-97

1

Nakamura, K., Sugano, H., Takagi, K. (1968) Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gan, 59(3): 251-8

Nishino, Y., Inoue, M., Tsuji, I., Wakai, K., Nagata, C., Mizoue, T., et al. (2006) Tobacco smoking and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 36(12): 800-7

Nomura, A.M., Hankin, J.H., Kolonel, L.N., Wilkens, L.R., Goodman, M.T., Stemmermann, G.N. (2003) Case-control study of diet and other risk factors for gastric cancer in Hawaii (United States). Cancer Causes Control, 14(6): 547-58

Olefson, S., Moss, S.F. (2015) Obesity and related risk factors in gastric cardia adenocarcinoma. Gastric Cancer, 18(1): 23-32

1

Parkin, D.M., Bray, F., Ferlay, J., Pisani, P. (2005) Global cancer statistics 2002. CA Cancer J Clin, 55(2): 74-108

Pinheiro, H., Oliveira, C., Seruca, R., Carneiro, F. (2014) Hereditary diffuse gastric cancer -pathophysiology and clinical management. Best Pract Res Clin Gastroenterol, 28(6): 1055-68

Ramos, M.F.K.P., Junior, U.R., Viscondi, J.K.Y., Zilberstein, B., Cecconello, I., Eluf-Neto, J. (2018) Risk factors associated with the development of gastric cancer -case control study. Rev Assoc Med Bras, 64(7): 611-19

Shah, S.C., Mckinley, M., Gupta, S., Peek, R.M. J., Martinez, M.E., Gomez, S.L. (2020) Population-Based Analysis of Differences in Gastric Cancer Incidence Among Races and Ethnicities in Individuals Age 50 Years and Older. Gastroenterology, 159(5): 1705-14

Singh, P.P., Singh, S. (2013) Statins are associated with reduced risk of gastric cancer: a systematic review and meta-analysis. Ann Oncol, 24(7): 1721-30

Singh, S., Varayil, J.E., Devanna, S., Murad, M.H., Iyer, P.G. (2014) Physical activity is associated with reduced risk of gastric cancer: A systematic review and meta-analysis. Cancer Prev Res, 7(1): 12-22

Sitarz, R., Skierucha, M., Mielko, J., Offerhaus, G.J.A., Maciejewski, R., Polkowski, W.P. (2018) Gastric cancer: Epidemiology, prevention, classification, and treatment. Cancer Manag Res, 10: 239-48

Stock, M., Otto, F. (2005) Gene deregulation in gastric cancer. Gene, 360(1): 1-19

Suerbaum, S., Michetti, P. (2002) Helicobacter pylori infection. N Engl J Med, 347(15): 1175-86

Tavani, A., Malerba, S., Pelucchi, C., Dal, M.L., Zucchetto, A., Serraino, D., et al. (2012) Dietary folates and cancer risk in a network of case-control studies. Ann Oncol, 23(10): 2737-42

Tseng, C-H., Tseng, F-H. (2014) Diabetes and gastric cancer: the potential links. World J Gastroenterol, 20(7): 1701-11

Vogelaar, I.P., van der Post, R.S., Jm, van K.J.H., Spruijt, L., Ag, van Z.W., Kets, C.M., et al. (2017) Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing. Eur J Hum Genet, 25(11): 1246-52

1

Warren, J.R., Marshall, B. (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet, 1(8336): 1273-5

Werner, M., Becker, K., Keller, G., Höfler, H. (2001) Gastric adenocarcinoma: Pathomorphology and molecular pathology. J Cancer Res Clin Oncol, 127(4): 207-16

Wong, M.C.S., Huang, J., Chan, P.S.F., Choi, P., Lao, X.Q., Chan, S.M., et al. (2021) Global Incidence and Mortality of Gastric Cancer, 1980-2018. JAMA Netw Open, 4(7): e2118457

Yang, H-J., Kang, D., Chang, Y., Ahn, J., Ryu, S., Cho, J., et al. (2020) Diabetes mellitus is associated with an increased risk of gastric cancer: a cohort study. Gastric Cancer, 23(2): 382-390

Yang, P., Zhou, Y., Chen, B., Wan, H-W., Jia, G-Q., Bai, H-L., et al. (2010) Aspirin use and the risk of gastric cancer: a meta-analysis. Dig Dis Sci, 55(6): 1533-9

Yusefi, A.R., Lankarani, K.B., Bastani, P., Radinmanesh, M., Kavosi, Z. (2018) Risk factors for gastric cancer: A systematic review. Asian Pac J Cancer Prev, 19: 591-603

Zhang, X.Y., Zhang, P.Y. (2017) Gastric cancer: Somatic genetics as a guide to therapy. J Med Genet, 54(5): 305-12

Zhang, X-L., Cui, Y-H. (2015) GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review. Onco Targets Ther, 8: 969-75
   

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article language: English
document type: Original Paper
DOI: 10.5633/amm.2023.0104
published in SCIndeks: 07/04/2023
peer review method: double-blind
Creative Commons License 4.0

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