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2014, vol. 67, iss. 3-4, pp. 97-99
Diagnosis of neurosarcoidosis: Necessity of biopsy
aClinical Center of Serbia, Clinic for Pulmonology, Belgrade
bClinical Center of Serbia, Clinic for Pulmonology, Belgrade + University of Belgrade, Faculty of Medicine
cClinical Center of Serbia, Clinic for Neurology, Belgrade
dClinical Center of Serbia, Clinic for Psychiatry, Belgrade
Clinical and epidemiological study of adverse events in hospital patients (MESTD - 175046)
Significance of early diagnosis of obstructive sleep apnea syndrome in professional drivers operating motor vehicles (MESTD - 175081)

Introduction: Sarcoidosis can affect any part of the central nervous system presenting with an extremely diverse clinical picture. Clinical presentations actually depend on the localization of granulomas in the central nervous system. Making diagnosis according to the localization and the clinical variations is often a clinical challenge. Diagnosis of Neurosarcoidosis. Diagnosis is based on the clinical picture, clinical and radiological findings (magnetic resonance imaging with contrast endocranium), laboratory findings (angio-tenzin-converting enzyme and chitotriosidase in cerebrospinal fluid); however, it is necessary first to exclude all other possible causes of granulomatous inflammation. Recent studies in patients with neurosarcoidosis show a high value of at least one marker of the disease. The safest way and the gold standard in diagnosing this disease would be histopathological confirmation, which is rarely performed due to its invasiveness. Conclusion. New diagnostic methods will contribute to better methods of bypassing invasive procedures, and they will significantly facilitate the diagnosis of neurosarcoidosis, which is a real challenge even for experienced clinicians who deal with this disease.
Filipović, S., Mihailović-Vučinić, V., Omčikus, M., Videnović-Ivanov, J., Stjepanović, M., Šumarac, Z. (2013) Hitotriozidaza-potencijalni biomarker u sarkoidozi. Med Pregl, Suppl 1, u štampi
Judson, M.A., Baughman, R.P., Teirstein, A.S., Terrin, M.L., Yeager, H. (1999) Defining organ involvement in sarcoidosis: the ACCESS proposed instrument. ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis, 16(1): 75-86
Judson, M.A., Baughman, R.P., Thompson, B.W., Teirstein, A.S., Terrin, M.L., Rossman, M.D., Yeager, H., McLennan, G., Bresnitz, E.A., DePalo, L., Hunninghake, G., Iannuzzi, M.C. (2003) Two year prognosis of sarcoidosis: the ACCESS experience. Sarcoidosis Vasc Diffuse Lung Dis, 20(3): 204-11
Khoury, J., Wellik, K.E., Demaerschalk, B.M., Wingerchuk, D.M. (2009) Cerebrospinal fluid angiotensin-converting enzyme for diagnosis of central nervous system sarcoidosis. Neurologist, 15(2): 108-11
Marangoni, S., Argentiero, V., Tavolato, B. (2006) Neurosarcoidosis. Clinical description of 7 cases with a proposal for a new diagnostic strategy. J Neurol, 253(4): 488-95
Mumović, G., Mitrović, M.S., Veselinović, M. (2008) Arbutina a potential new marker of sarcoidosis severity. Respiration, 76(2): 234-238
Savić, M., Stjepanović, M., Mihailović-Vučinić, V., Gvozdenović, B., Filipović, S., Mujović, N. (2013) Sarkoidoza-novine u dijagnostici. Med Pregl, 66(suppl. 1): 22-25
Stjepanović, M., Mihailović-Vučinić, V., Mijajlovic, M., Videnović-Ivanov, J., Filipović, S., Omčikus, M., i dr. (2013) Dijagnostika neurosarkoidoze, novine i naša iskustva. Journal of the Association of pulmologists from Republic of Srpska, 3(1-2): 18
Stjepanović, M., Mihailović-Vučinić, V., Dudvarski-Ilić, A., Videnović-Ivanov, J., Škodrić-Trifunović, V., Popević, S. (2013) Kliničke manifestacije neurosarkoidoze. Med Pregl, 66(suppl. 1): 54-59
Stjepanović, M. (2013) Vanplućne komplikacije plućne sarkoidoze-neurosarkoidoza: evaluacija, terapija i komplikacije zahvaćenosti nervnog sistema. Beograd: Medicinski fakultet, Univerzitet u Beogradu, Akademski specijalistički rad
Škodrić-Trifunović, V., Vučinić, V., Simić-Ogrizović, S., Stević, R., Stjepanović, M., Ilić, K., Savić, Ž. (2012) Mystery called sarcoidosis: Forty-four years follow-up of chronic systemic disease. Srpski arhiv za celokupno lekarstvo, vol. 140, br. 11-12, str. 768-771
Terushkin, V., Stern, B.J., Judson, M.A., Hagiwara, M., Pramanik, B., Sanchez, M., Prystowsky, S. (2010) Neurosarcoidosis: presentations and management. Neurologist, 16(1): 2-15
Zajicek, J.P., Scolding, N.J., Foster, O., Rovaris, M., Evanson, J., Moseley, I.F., Scadding, J.W., Thompson, E.J., Chamoun, V., Miller, D.H., McDonald, W.I., Mitchell, D. (1999) Central nervous system sarcoidosis: diagnosis and management. QJM, 92(2): 103-17


article language: English
document type: Review Paper
DOI: 10.2298/MPNS1404097S
published in SCIndeks: 11/04/2014

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