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2021, vol. 78, br. 4, str. 397-402
Povezanost tipa preloma i formiranja kalusa sa koncentracijom proinflamatornih citokina kod dece sa prelomima dugih kostiju
aUniverzitet u Beogradu, Medicinski fakultet, Institut za zdravstvenu zaštitu majke i deteta Republike Srbije 'Dr Vukan Čupić'
bUniverzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd
cEmergency Medical Center of Montenegro, Podgorica, Montenegro
dUniverzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd + Vojnomedicinska akademija, Institut za medicinska istraživanja, Beograd
eUniversity of Nantes, Faculty of Dental Surgery, Nantes, France + Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković'
fUniverzitet u Beogradu, Farmaceutski fakultet
gUniverzitet u Novom Sadu, Medicinski fakultet
hUniversity of Cambridge, Addenbrooke's Hospital, Division of Trauma and Orthopedic Surgery, Cambridge, United Kingdom
iUniverzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd + Vojnomedicinska akademija, Klinika za ortopedsku hirurgiju i traumatologiju, Beograd

e-adresastarcevicdrsrdjan@gmail.com
Ključne reči: prelomi; prelomi, zarastanje; deca; adolescenti; kalus; interleukin-1beta; faktor nekroze tumora-alfa; monocitni hemoatraktantni protein-1; interleukin-8; prognoza
Sažetak
Uvod/Cilj. Inflamatorni odgovor je od izuzetne važnosti u zarastanju koštanih preloma, iako je precizna uloga ćelija i citokina nejasna. U našoj studiji ispitivali smo povezanost vrednosti interleukina-1b (IL-1b), faktora nekroze tumora-alfa (TNF-a), monocitni hemoatraktantni protein-1 (MCP-1) i interleukina-8 (IL-8) sa konfiguracijom preloma i formiranjem kalusa. Metode. Serumska koncentracija citokina određivana je kod 78 negojazne dece sa prelomom dugih kostiju (grupa 1), 10 dece sa prelomom prstiju (grupa 2) i 10 zdrave dece (grupa 3 - kontrolna grupa). Uzorci krvi kod dece sa prelomima kostiju uzimani su odmah po prijemu u bolnicu (grupe 1 i 2). Razlike u koncentracijama citokina su analizirane između grupa i kategorisane prema konfiguraciji preloma i formiranju kalusa. Rezultati. Vrednosti IL1-b i TNF-a bile su niže kod bolesnika sa nedovoljno formiranim kalusom u odnosu na one sa kompletnim kalusom. Iznenađujuće, prosečna IL1-b koncentracija bila je najveća u kontrolnoj grupi. Jedina značajna korelacija između IL1-b i TNF-a bila je u grupi sa intermedijarno formiranim kalusom. MCP-1 je imao povišene vrednosti kod svih bolesnika u odnosu na kontrolnu grupu, bez međusobnih razlika. Prosečna vrednost IL-8 pokazala je jasan pad u grupi sa nekompletno formiranim kalusom u odnosu na grupu sa kompletno formiranim kalusom i kontrolnu grupu, ali bez značajne razlike. Deca sa epifiziolizom imala su najmanje koncentracije citokina u poređenju sa svim drugim tipovima preloma. Takođe smo detektovali značajno niže koncentracije IL-1b i MCP-1 kod bolesnika sa manjim stepenom dislokacije u odnosu na veće dislokacije fragmenata. Zaključak. Sistemski inflamatorni odgovor je važan u fiziološkom zarastanju kostiju. Visoka rana produkcija IL1-b, TNF-a i MCP-1 je udružena sa boljim formiranjem kalusa i boljim zarastanjem kostiju, dok je povećana IL-8 koncentracija udružena sa lošim formiranjem kalusa i lošim zarastanjem kostiju. Naši rezultati su pokazali da su epifizioliza i veći stepen dislokacije fragmenata udruženi sa odloženim zarastanjem fraktura.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP190526078P
primljen: 26.05.2019.
prihvaćen: 21.06.2019.
objavljen onlajn: 15.09.2019.
objavljen u SCIndeksu: 07.05.2021.
metod recenzije: dvostruko anoniman
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