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2020, vol. 148, br. 1-2, str. 48-51
Benigna prolazna hiperfosfatazemija kod dece
aSrpsko lekarsko društvo, Akademija medicinskih nauka, Beograd
bUniverzitet u Beogradu, Medicinski fakultet, Univerzitetska dečija klinika + Univerzitet u Beogradu, Medicinski fakultet
cUniverzitet u Beogradu, Medicinski fakultet, Univerzitetska dečija klinika
dMedicinski centar 'Valjevo', Valjevo
eOpšta bolnica 'Novi Pazar', Novi Pazar
fUniverzitet u Banjoj Luci, Medicinski fakultet, Republika Srpska, BiH

e-adresan.radlovic@botel.net
Ključne reči: benigna prolazna hiperfosfatazemija; dijagnostika; deca
Sažetak
Uvod/Cilj Benigna prolazna hiperfosfatazemija (BPHF) predstavlja patogenetski nedovoljno jasan klinički entitet, koji se pretežno viđa kod odojčadi i male dece. Cilj rada je da se iznesu naša iskustva vezana za uzrast javljanja, okolnosti otkrivanja i dužinu trajanja BPHF kod dece. Metode Rad je realizovan na uzorku od 18 dece - devet dečaka i devet devojčica, uzrasta 10-42 (21,06 ± 9,35) meseca sa BPHF. Dijagnoza BPHF je bazirana na odsustvu koštanih i hepatobilijarnih oboljenja, kao i njenom spontanom iščezavanju tokom nekoliko narednih meseci. Rezultati Jedno dete je bilo u prvoj godini, 13 u drugoj, tri u trećoj i jedno u četvrtoj. Izolovana visoka aktivnost serumske alkalne fosfataze, koja je bila 2,04-21,9 (8,05 ± 5,31) puta iznad gornje referentne vrednosti za odgovarajuću starost, kod 14 slučajeva je nađena u okviru akutne dijareje i kod četiri slučaja sa akutnim rinofaringitisom, od čega kod dva sa komplikovanim otitisnim medijem. Uzrok dijareje u šest slučajeva bio je rotavirus, u dva slučaja kampilobakterija i u jednom slučaju adenovirus, a uzrok otitisnog medija u jednom slučaju bile su streptokoke pneumonije, dok kod ostalih etiološki činilac infekcije nije identifikovan. Spontana normalizacija serumske aktivnosti alkalne fosfataze registrovana je između jednog i tri meseca. Zaključak BPHF predstavlja bezazlen biohemijski poremećaj koji se spontano povlači unutar tri meseca posle inicijalne opservacije. Otkriva se slučajno kao rutinski laboratorijski nalaz najčešće u sklopu tretmana akutnih gastrointestinalnih i respiratornih infekcija.
Reference
Akcaboy, M., Zorlu, P., Acoglu, E.A., Acar, M., Oguz, M.M., Senel, S. (2016) Human bocavirus infection associated transient benign hyperphosphatasemia in an infant. Indian Journal of Pediatrics, 83(8): 902-903
Arikan, C., Arslan, M.T., Kilic, M., Aydogdu, S. (2006) Transient hyperphosphatasemia after pediatric liver transplantation. Pediatrics International, 48(4): 390-392
Bassrawi, R., Alsabie, N., Alsorani, D., Babiker, A. (2014) Transient hyperphosphatasemia in children. Sudan J Paediatr, 14(2):85-8
Çakır, B.C., Kirsaçlioğlu, C.T., Tartıcı, E.K., Demirel, F. (2017) Transient hyperphosphatasemia in infants and children: A retrospective study of 43 cases. J Contemp Med, 7(2):138-42
Chesney, R.W. (2016) Hyperphosphatasia. u: Kliegman R.M; Stanton B.F; St Game J.W. III; Schor N.F. [ur.] Nelson textbook of pediatrics, Philadelphia: Elsevier, p. 3394-5
Chu, A.S., Rothschild, J.G. (2016) Update on benign transient hyperphosphatasemia: Recognizing an underappreciated condition. Clin Pediatr, Phila, 55(6):564-6
D'Alessandro, D.M. (2010) What is the differential diagnosis of hyperphosphatasemia?. PediatricEducation.org, May 17, http://pediatriceducation.org/2010/05/17/what-is-the-differential-diagnosis-of-hyperphosphatasemia/ [cited 2015 May 15]
Dori, N., Levi, L., Stam, T., Sukhotnik, I., Shaoul, R. (2010) Transient hyperphosphatasemia in children revisited. Pediatrics International, 52(6): 866-871
Eymann, A., Cacchiarelli, N., Alonso, G., Llera, J. (2010) Benign transient hyperphosphatasemia of infancy: A common benign scenario, a big concern for a pediatrician. Journal of Pediatric Endocrinology and Metabolism, 23(9): 927-957
Giannini, E.G., Testa, R., Savarino, V. (2005) Liver enzyme alteration: A guide for clinicians. Canadian Medical Association Journal, 172(3): 367-379
Gualco, G., Lava, S.A.G., Garzoni, L., Simonetti, G.D., Bettinelli, A., Milani, G.P., Provero, M.C., Bianchetti, M.G. (2013) Transient benign hyperphophatasemia. Journal of Pediatric Gastroenterology and Nutrition, 57(2): 167-171
Hoshino, T., Kumasaka, K., Kawamo, K., Yamagishi, F., Sakai, H., Komoda, T. (1993) A case of Benign familial hyperphosphatasemia of intestinal origin. Clinical Biochemistry, 26(5): 421-425
Hoylaerts, M.F., van Kerckhoven, S., Kiffer-Moreira, T., Sheen, C., Narisawa, S., Millán, J.L. (2015) Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase. PLoS One, 10(3): e0119874-e0119874
Jassam, N.J., Horner, J., Marzo-Ortega, H., Sinclair, M., Barth, J.H. (2009) Transient rise in alkaline phosphatase activity in adults. BMJ Case Reports
Koike, Y., Aoki, N. (2013) Benign transient hyperphosphatasemia associated with Epstein-Barr virus infection. Pediatrics International, 55(5): 667-668
Kutilek, S., Cervickova, B., Bebova, P., Kmonickova, M., Nemec, V. (2012) Normal bone turnover in transient hyperphosphatasemia. Journal of Clinical Research in Pediatric Endocrinology, 4(3): 154-156
Kutílek, Š., Skálová, S., Vethamuthu, J., Geier, P., Feber, J. (2012) Transient hyperphosphatasemia in pediatric renal transplant patients: Is there a need for concern and when?. Pediatric Transplantation, 16(1): E5-E9
Massey, G.V., Dunn, N.L., Heckel, J.L., Chan, J.C.M., Russell, E. C. (1996) Benign transient hyperphosphatasemia in children with leukemia and lymphoma. Clinical Pediatrics, Phila, 35(10): 501-504
Millán, J.L. (2006) Alkaline phosphatases: Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes. Purinergic Signal, 2(2):335-41
Millán, J.L., Whyte, M.P. (2016) Alkaline phosphatase and hypophosphatasia. Calcified Tissue International, 98(4): 398-416
Mori, T., Tanaka, R., Nishida, K., Yamamoto, N., Hayakawa, A., Nishimura, N., Nozu, K., Iijima, K. (2016) Transient hyperphosphatasemia in three pediatric patients treated with cyclosporine. Pediatrics International, 58(5): 429-430
Rosalki, S.B., Foo, A.Y., Dooley, J.S. (1993) Benign familial hyperphosphatasaemia as a cause of unexplained increase in plasma alkaline phosphatase activity. Journal of Clinical Pathology, 46(8): 738-741
Sardiwal, S., Gardham, C., Coleman, A.E., Stevens, P.E., Delaney, M.P., Lamb, E.J. (2012) Bone-specific alkaline phosphatase concentrations are less variable than those of parathyroid hormone in stable hemodialysis patients. Kidney International, 82(1): 100-105
Shapira, M., Shaoul, R. (2015) An 18-month-old boy with diarrhea and an elevated biochemical parameter. Pediatric Annals, 44(6): 232-234
Sharma, U., Pal, D., Prasad, R. (2014) Alkaline phosphatase: An overview. Indian Journal of Clinical Biochemistry, 29(3): 269-278
Suzuki, M., Okazaki, T., Nagai, T., Törõ, K., Sétonyi, P. (2002) Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunology & Medical Microbiology, 33(3): 215-218
Teitelbaum, J.E., Laskowski, A., Barrows, F.P. (2011) Benign transient hyperphosphatasemia in infants and children: A prospective cohort. Journal of Pediatric Endocrinology and Metabolism, 24(1-2): 93-98
van Hoof, V.O., de Broe, M.E. (1994) Interpretation and clinical significance of alkaline phosphatase isoenzyme patterns. Critical Reviews in Clinical Laboratory Sciences, 31(3): 197-293
Yoshimaru, K., Matsuura, T., Hayashida, M., Kinoshita, Y., Takahashi, Y., Yanagi, Y., Esumi, G., Taguchi, T. (2016) Transient hyperphosphatasemia after pediatric liver transplantation. Pediatrics International, 58(8): 726-731
 

O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/SARH180904083R
objavljen u SCIndeksu: 06.03.2020.