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2004, vol. 57, br. 1-2, str. 45-53
Fosinopril i amlodipin u lečenju izolovane sistolne hipertenzije
Univerzitet u Novom Sadu, Medicinski fakultet, Institut za kardiovaskularne bolesti
Sažetak
Cilj istraživanja bilo je tromesečno praćenje terapijskih efekata fosinoprila (F) i amlodipina (A) na regulaciju i dnevno-noćni ritam krvnog pritiska, i LVM kod pacijenata starosti preko 60 godina sa izolovanom sistolnom hipertenzijom. Nakon 1 nede- lje placebo pripremnog perioda, 60 bolesnika podeljeno je u dve grupe po 30, koje su tertirane 3 meseca fosinoprilom, ili amlodipinom. Pre uvođenja leka i nakon 3 meseca rađeni su: klinički, ehokardiografski pregled, i 24-satno ambulantno merenje krvnog pritiska. Ciljna vrednost pritiska £ 140/90 mmHg, postignuta je u preko 2/3 slučajeva (F 76,6%, a A 79,9%), a niže doze su bile potrebne u grupi u kojoj je primenjivan F. Kod 13 pacijenata nisu postignute ciljne vrednosti, pa su lečeni još 1 mesec, kombinacijom oba leka. Kod 10 (76,9%) postignuta je adekvatna regulacija TA. Fosinopril i amlodipin efikasno kontrolišu krvni pritisak pri jednokratnom doziranju, značajno utiču na njegov dnevno-noćni ritam i daju regresiju hipertrofije miokarda. Manjim dozama fosinoprila, postiže se adekvatna kontrola TA uz povoljan efekat na dnevno-noćni ritam.
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O članku

jezik rada: srpski
vrsta rada: stručni članak
DOI: 10.2298/MPNS0402045P
objavljen u SCIndeksu: 02.06.2007.

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