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2021, vol. 2, iss. 2, pp. 75-81
Characteristics of patients with secondary erythrocytosis in relation to patients with polycythemia vera
aClinical Center of Serbia, Clinic for Eye Diseases, Belgrade
bClinical Center of Serbia, Clinic for Hematology, Belgrade + University of Belgrade, Faculty of Medicine
cClinical Center of Serbia, Clinic for Hematology, Belgrade

emaildanijela.lekovic@yahoo.com
Keywords: secondary erythrocytosis; polycythemia vera; differential diagnosis
Abstract
Introduction: Erythrocytosis represents elevated hemoglobin and hematocrit levels above the range of normal values. Primary erythrocytosis - polycythemia vera, is characterized by increased erythrocyte production, due to a disorder at the level of the multipotent stem cell in the bone marrow. On the other hand, secondary erythrocytosis (SE) is the result of bone marrow stimulation by an external factor. Aim: The aim of our study was to determine parameters which are significant in differentiating SE from primary erythrocytosis - polycythemia vera (PV). Materials and methods: This is a retrospective study involving 108 patients with SE and 111 patients with PV, who were diagnosed and treated at the Clinic of Hematology of the Clinical Center of Serbia (CCS), in the period: December 2005 - November 2018.From the patient records, the following data were extracted: demographic characteristics, laboratory parameters, spleen size, total red cell mass, serum erythropoietin (EPO) level, and spontaneous growth of the BFU-E colony. Results: Patients with SE were younger, with a predominance of the male gender and with significantly higher serum EPO values than patients with PV. Patients with PV had significantly higher values of BFU-E, leukocyte and platelet count, spleen size, and LDH level than patients with SE. Total red cell mass analysis did not show a differential diagnostic significance. Conclusion: Findings of normal spleen size, normal leukocyte and platelet count, normal serum LDH level, and elevated EPO, in patients, refer to the diagnosis of secondary erythrocytosis, while the findings of splenomegaly, leukocytosis, thrombocytosis, elevated serum LDH level, decreased EPO, and the presence of spontaneous BFU-E colony speak in favor of the diagnosis of polycythemia vera.
References
Barbui, T., Thiele, J., Gisslinger, H., Kvasnicka, H.M., Vannucchi, A.M., Guglielmelli, P., Orazi, A., Tefferi, A. (2018) The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: Document summary and in-depth discussion. Blood Cancer Journal, 8(2): 15
Gagnon, D.R., Zhang, T.J., Brand, F.N., Kannel, W.B. (1994) Hematocrit and the risk of cardiovascular disease: The framingham study: A 34-year follow-up. American Heart Journal, 127(3): 674-682
Kralovics, R., Passamonti, F., Buser, A.S., Teo, S., Tiedt, R., Passweg, J.R., Tichelli, A., Cazzola, M., Skoda, R.C. (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. New England Journal of Medicine, 352(17): 1779-1790
McMullin, M.F., Bareford, D., Campbell, P., Green, A.R., Harrison, C., Hunt, B., Oscier, D., Polkey, M.I., Reilly, J.T., Rosenthal, E., Ryan, K., Pearson, T.C., Wilkins, B. (2005) Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis. British Journal of Haematology, 130(2): 174-195
Pearson, T.C., Guthrie, D.L., Simpson, J., Chinn, S., Barosi, G., Ferrant, A., Lewis, S.M., Najean, Y. (1995) Interpretation of measured red cell mass and plasma volume in adults: Expert panel on radionuclides of the international council for standardization in haematology. British Journal of Haematology, 89(4): 748-756
Prchal, J.F., Axelrad, A.A. (1974) Bone-marrow responses in polycythemia vera. New England Journal of Medicine, 290(24): 1382
Scott, L.M., Tong, W., Levine, R.L. (2007) JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med, 356: 459-68
 

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article language: Serbian, English
document type: Original Paper
DOI: 10.5937/smclk2-32336
received: 20/05/2021
revised: 25/05/2021
accepted: 26/05/2021
published online: 25/06/2021
published in SCIndeks: 14/07/2021

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