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2013, vol. 63, br. 3, str. 279-292
Interakcije lekova i DNK- osobine i detekcija
aUniverzitet u Beogradu, Farmaceutski fakultet, Institut za fizičku hemiju, Srbija
bUniverzitet u Beogradu, Farmaceutski fakultet, Institut za analitičku hemiju, Srbija

e-adresamara@pharmacy.bg.ac.rs
Projekat:
Sinteza, kvantitativni odnos između strukture i dejstva, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (MPNTR - 172033)

Ključne reči: Lek; DNK; interakcija; spektroskopske metode; DNK-biosenzori
Sažetak
Komplekse sa dezoksiribonukleinskom kiselinom (DNK) gradi veliki broj neorganskih i organskih jedinjenja, među kojima su od posebnog značaja lekovi iz grupe hemioterapeutika. U radu je dat pregled strukturnih karakteristika DNK molekula i tipova interakcije (kovalentne i nekovalentne) koje se javljaju između molekula leka i DNK. Kovalentno vezivanje leka za DNK je ireverzibilno i vodi ka kompletnoj inhibiciji funkcija DNK što dovodi do smrti ćelije, dok je nekovalentno vezivanje reverzibilno i zasniva se na principu molekularnog prepoznavanja. Posebna pažnja je posvećena objašnjenju specifičnih mesta u molekulu DNK Na kojima dolazi do vezivanja leka, u zavisnosti od strukturnih karakteristika molekula leka. Najveći broj lekova koji reaguju nekovalentno su interkalatni agensi, a pored njih postoje i lekovi koji se vezuju za mali ili veliki žljeb molekula DNK. Prilikom građenja ovih kompleksa nastaju promene kako na molekulu DNK tako i na molekulu leka. U radu je dat pregled metoda koje se koriste u ispitivanju interakcija između leka i DNK sa ciljem detekcije i objašnjenja nastalih promena. U ovu svrhu koriste se spektroskopske metode, kao što su UV/VIS, infracrvena, ramanska i NMR spektroskopija, zatim spektroskopije polarizovane svetlosti: metode linearnog i cirkularnog dihroizma, fluorescentne anizotropije ili rezonancije, a u novije vreme i osetljivi DNK-biosenzori. Predstavljeni su literaturni rezultati dobijeni primenom navedenih metoda koji se koriste za utvrđivanje oštećenja na DNK molekulu, određivanje mesta specifičnog vezivanja leka, redosleda vezivanja, kao i za detekciju konformacionih promena nastalih usled lek-DNK interakcije.
Reference
Banyay, M., Sarkar, M., Gräslund, A. (2003) A library of IR bands of nucleic acids in solution. Biophysical Chemistry, 104(2): 477-488
Barber, J., Cross, H.F., Parkinson, J.A. (1993) High-resolution NMR of DNA and drug-DNA interactions. u: Jones C., Mulloy B., Thomas A.H. [ur.] Methods in Molecular Biology, Spectroscopic Methods and Analyses: NMR Mass Spectrometry, and Metalloprotein Techniques, Totowa, NJ: Humana Press, Vol 17, str. 87-113
Barber, J., Cross, H.F., Parkinson, J.A. (1993) High-Resolution NMR of DNA and Drug-DNA Interactions. Spectroscopic Methods and Analyses, str. 87-114
Boyer, R. (2006) Concepts in Biochemistry. New Jersey: John Wiley
Brett, A.M.O., Diculescu, V.C., Chiorcea-Paquim, A.M., Serrano, S.H.P. (2007) DNA -electrochemical biosensors for investigating DNA damage. u: Alegret S.; Merkoci A. [ur.] Electrochemical Sensors Analysis, Amstredam: Elsevier Science B. V, 413-438
Cardew, A.T., Fox, K.R. (1993) DNase I foot printing. u: Fox K.R. [ur.] Methods in Molecular Biology: Drug-DNA Interaction Protocols, Totowa, NJ: Humana Press, 2nd ed., chapter 10, 153-72
Chaires, J.B. (1998) Drug-DNA interactions. Curr Opin Struc Biol., 8: 314-320
Eriksson, M., Norden, B. (2001) Linear and circular dichroism of drug-nucleic acid complexes. Methods Enzymol, 340, str. 68-98
Galas, D.J., Schmitz, A. (1978) DNAase footprinting a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Research, 5(9): 3157-3170
Hamilton, P.L., Arya, D.P. (2012) Natural product DNA major groove binders. Natural product reports, 29(2): 134-43
Hampshire, A.J., Rusling, D.A., Broughton-Head, V.J., Fox, K.R. (2007) Footprinting: a method for determining the sequence selectivity, affinity and kinetics of DNA-binding ligands. Methods (San Diego, Calif.), 42(2): 128-40
Hannon, M.J. (2007) Supramolecular DNA recognition. Chemical Society Reviews, 36(2): 280
Huang, C.H., Mirabelli, C.K., Mong, S., Crooke, S.T. (1983) Intermolecular Cross linking of DNA through Bifunctional Intercalation of an Antitumor Antibiotic, Luzopeptin A. Cancer Res., 43: 2718-2724
Islam, M., Chowdhury, S.R., Kumar, G.S. (2009) Spectroscopic and Calorimetric Studies on the Binding of Alkaloids Berberine, Palmatine and Coralyne to Double Stranded RNA Polynucleotides. Journal of Physical Chemistry B, 113(4): 1210-1224
Jangir, D.K., Tyagi, G., Mehrotra, R., Kundu, S. (2010) Carboplatin interaction with calf-thymus DNA: A FTIR spectroscopic approach. Journal of Molecular Structure, 969(1-3): 126-129
Kennard, O. (1993) DNA-drug interactions. Pure and Applied Chemistry, 65(6): 1213-1222
Kennard, O., Hunter, W.N. (1991) Single-Crystal X-Ray Diffraction Studies of Oligonucleotides and Oligonucleotide-Drug Complexes. Angewandte Chemie International Edition in English, 30(10): 1254-1277
Kerman, K., Kobayashi, M., Tamiya, E. (2004) Recent trends in electrochemical DNA biosensor technology. Measurement Science and Technology, 15(2): R1-R11
Kim, S.K., Norden, B. (1993) Methyl green A DNA major-groove binding drug. Fed Eur Biochem Soc Lett., 315(1): 61-64
Kumar, C.V., Turner, R.S., Asuncion, E.H. (1993) Groove binding of a styrylcyanine dye to the DNA double helix: the salt effect. Journal of Photochemistry and Photobiology A: Chemistry, 74(2-3): 231-238
Labuda, J., Brett, A.M.O., Evtugyn, G., Fojta, M., Mascini, M., Ozsoz, M., Palchetti, I., Paleček, E., Wang, J. (2010) Electrochemical nucleic acid-based biosensors: Concepts, terms, and methodology (IUPAC Technical Report). Pure and Applied Chemistry, 82(5): 1161-1187
Liébana, S., Lermo, A., Campoy, S., Barbé, J., Alegret, S., Pividori, M.I. (2009) Magneto Immunoseparation of Pathogenic Bacteria and Electrochemical Magneto Genosensing of the Double-Tagged Amplicon. Analytical Chemistry, 81(14): 5812-5820
Mandeville, J.S., N’soukpoé-Kossi, C.N., Neault, J.F., Tajmir-Riahi, H.A. (2010) Structural analysis of DNA interaction with retinol and retinoic acid. Biochemistry and Cell Biology, 88(3): 469-477
Moravek, Z. (2002) Protein and drug interactions in the minor groove of DNA. Nucleic Acids Research, 30(5): 1182-1191
Nakamoto, K., Tsuboi, M., Strahan, G.D. (2008) Drug-DNA Interactions: Structures and spectra. Hoboken, New Jersey: John Wiley & Sons
Neidle, S. (2008) Principles of nucleic acid structure. Amsterdam: Elsevier, str. 151-158
Neidle, S. (2001) DNA minor-groove recognition by small molecules (up to 2000). Natural Product Reports, 18(3): 291-309
Ovâdekovâ, R., Labuda, J. (2006) Electrochemical DNA biosensors for the investigation of dsDNA host- guest interactions and damage. Curr. Top. Electrochem, 11: 21-56
Ovâdekovâ, R., Labuda, J. (2007) DNA binding interactions, structural damage and protection investigated by electrochemical DNA biosensor. u: Adam V., Kizek R. [ur.] Utilizing of Bio Electrochemical and Mathematical Methods in Biological Research, Kerala, India: Research Signpost, 173-201
Palecek, E., Jelen, F. (2005) u: Palecek E., Scheller F., Wang J. [ur.] Electrochemistry of nucleic acids and proteins: Towards electrochemical sensors for genomics and proteomics, Amstredam: Elsevier, str. 74-174
Paleček, E., Brabec, V. (1972) The relation between the polarographic behaviour of DNA and its conformation in solution. Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 262(2): 125-134
Radulović, V., Aleksić, M.M., Kapetanović, V. (2012) Elektrohemijsko ispitivanje adsorpcije i interakcije vareniklina i DNK. Journal of the Serbian Chemical Society, vol. 77, br. 10, str. 1409-1422
Rodger, A. (2010) Circular and linear dichroism of drug-DNA systems. Methods in molecular biology (Clifton, N.J.), 613: 37-54
Simkova, D., Labuda, J. (2011) Electrochemical DNA Biosensors and Flow-Through Analysis. A Review. Current Analytical Chemistry, 7(1): 2-7
Singh, N.N., Lambowitz, A.M. (2001) Interaction of a group II intron ribonucleoprotein endonuclease with its DNA target site investigated by DNA footprinting and modification interference. Journal of molecular biology, 309(2): 361-86
Suh, D., Chaires, J.B. (1995) Criteria for the mode of binding of DNA binding agents. Bioorganic & Medicinal Chemistry, 3(6): 723-728
Tajmir-Riahi, H.A. (1996) Diethylstilbestrol-DNA Interaction Studied by Fourier Transform Infrared and Raman Spectroscopy. Journal of Biological Chemistry, 271(14): 8140-8143
Teles, F., Fonseca, L. (2008) Trends in DNA biosensors. Talanta, 77(2): 606-623
Tian, X., Song, Y., Dong, H., Ye, B. (2008) Interaction of anticancer herbal drug berberine with DNA immobilized on the glassy carbon electrode. Bioelectrochemistry, 73(1): 18-22
Voet, D., Voet, J.G., Pratt, C.W. (2008) Fundamentals of biochemistry - life at the molecular level. Hoboken: John Wiley & Sons
Wang, A.H.J., Liaw, Y.C., Robinson, H., Gao, Y.G. (1990) u: Pullman B., Jortner J. [ur.] Molecular Basis of Specificity in Nucleic Acid-Drug Interactions, 23rd Jerusalem Symposium on Quantum Chemistry and Biochemistry, May 14-17, Jerusalem, Israel, Proceedings, Heidelberg: Kluwer Academic Publishers, 1-121
Wang, J. (2005) Electrochemical nucleic acid biosensors. u: Palecek E., Scheller F., Wang J. [ur.] Electrochemistry of nucleic acids and proteins: Towards electrochemical sensors for genomics and proteomics, Amstredam: Elsevier, str. 175-94
Wu, F.Y., Xiang, Y.L., Wu, Y.M., Xie, F.Y. (2009) Study of the Interaction of a Fluorescent Probe with DNA. J Lumin, 129(11): 1286-1291
Zubay, G.L., Parson, W.W., Vance, D.E. (1995) The principles of biochemistry. Boston: McGraw-Hill College, 627-677
Živanović, M., Aleksić, M., Ostatná, V., Doneux, T., Paleček, E. (2010) Polylysine-Catalyzed Hydrogen Evolution at Mercury Electrodes. Electroanalysis, 22(17-18): 2064-2070
 

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jezik rada: srpski
vrsta rada: pregledni članak
objavljen u SCIndeksu: 02.09.2013.

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