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2021, vol. 71, br. 2, str. 101-119
Bezbednost i efikasnost inhibitora interleukina u terapiji reumatoidnog artritisa, psorijaze i psorijaznog artritisa u populaciji starih osoba
aUniverzitet u Beogradu, Farmaceutski fakultet
bUniverzitet u Beogradu, Farmaceutski fakultet, Institut za mikrobiologiju i imunologiju

e-adresajasmina@pharmacy.bg.ac.rs
Ključne reči: inhibitori interleukina; stari pacijenti; bezbednost; efikasnost
Sažetak
Stariji pacijenti koji boluju od reumatoidnog artritisa, psorijaze ili psorijaznog artritisa uključuju one kod kojih je bolest imala kasni početak, nakon 60. godine starosti, ali takođe i one pacijente kod kojih je bolest počela ranije, a koji su ušli u staro doba. Imajući u vidu starenjem uslovljene promene imunskog sistema, moguću slabost starijih, podložnost infekcijama, prateći komorbiditet, koji uključuje i uzimanje više lekova, terapija ovih bolesti kod starijih pacijenata može predstavljati izazov. Inhibitori interleukina su se pokazali kao efikasna i bezbedna terapija ovih poremećaja. Međutim, stariji pacijenti sa ovim bolestima su često bili nedovoljno zastupljeni u ključnim kliničkim ispitivanjima inhibitora interleukina da bi se moglo sa sigurnošću utvrditi da postoji razlika u terapijskom odgovoru kod ovih pacijenata u odnosu na isti kod mlađih pacijenata. Cilj ovog rada bio je da prikaže nalaze od značaja za bezbednost i efikasnost terapije inhibitorima interleukina kod starijih pacijenata sa reumatoidnim artritisom, psorijazom ili psorijaznim artritisom. Nalazi ukazuju da je efikasnost inhibitora interleukina, prikazanih u ovom radu, uporediva kod starijih i mlađih pacijenata. Osim toga, incidencija neželjenih događaja se nije razlikovala između ove dve starosne grupe. Veća incidencija teških neželjenih događaja kod starijih pacijenata u odnosu na mlađe bila je zabeležena u terapiji reumatoidnog artritisa sarilumabom i psorijaze secukinumabom. Terapija reumatoidnog artritisa, psorijaze i psorijaznog artritisa inhibitorima interleukina može se smatrati efikasnom i bezbednom u populaciji starih pacijenata.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/arhfarm71-30505
objavljen u SCIndeksu: 29.04.2021.
metod recenzije: jednostruko anoniman
Creative Commons License 4.0

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