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2018, vol. 75, br. 8, str. 820-825
Centralni nervni sistem nije imunoprivilegovan - inflamacija i epileptogeneza
Univerzitet u Beogradu, Medicinski fakultet, Institut za fiziologiju

e-adresasolja@afrodita.rcub.bg.ac.rs
Projekat:
Razvoj animalnih modela epilepsije i testiranje konvulzivnih i antikonvulzivnih supstanci (MPNTR - 175032)

Sažetak
(ne postoji na srpskom)
Many neurological conditions and disorders, in the first raw inflammatory diseases of the CNS (meningitis, encephalitis), CNS injuries, stroke, etc., are associated with inflammation. On the other hand, clinical course of these disorders frequently includes seizures. Inflammation is a common factor that disrupts homeostasis in the CNS neural networks; it acts proepileptogenically and causes seizures. Taking into account all the above-mentioned facts, it is clear that neuroinflammation, together with its specific relation to ROS and changes in neural ECM, is interconnected with epileptogenesis, being its cause, or a consequence. Neuroinflammation reduces the threshold for initiation of the CNS hyperexcitability and disrupts the competency of the BBB. It is reasonable to assume that therapeutic treatment of peripheral inflammation alongside with neuroinflammation can provide beneficial effects for patients with epilepsy by reducing the seizure number. Thus, this is a promising alley of future therapeutic modalities in epileptology.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.2298/VSP160920392H
objavljen u SCIndeksu: 30.08.2018.
metod recenzije: dvostruko anoniman
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