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2021, vol. 36, br. 1, str. 45-59
Nefroprotektivno delovanje vodenog acetonskog ekstrakta Morus alba i mehanizam toksičnosti indukovane glifosatom - in vivo model
aUniversity of Tunis El Manar, Faculty of Science of Tunis, Department of Biological Sciences, Research Unit of Functional Neurophysiology and Pathology, Tunis, Tunisia
bUniversity of Carthage, INSAT, Laboratoire de Biochimie Alimentaire,Tunis, Tunisia

e-adresaolfa.rebai@yahoo.fr
Projekat:
This work was supported by the Research Unit 00-UR-08-01, University of Sciences, Tunis, and by a grant from the Ministry of Higher Education and Scientific Research of Tunisia

Ključne reči: glifosat; oksidativni stres; nefrotoksičnost; beli dud; nefroprotektivno delovanje
Sažetak
Glifosat, aktivna materija preparata Roundup®, je pesticid koji je u najširoj upotrebi u svetu i njegovi ostaci se mogu naći u prerađenoj hrani i pijaćoj vodi. Ranija istraživanja su potvrdila da ekstrakti lista Morus alba poseduju farmakološko dejstvo. Međutim, renoprotektivno delovanje ekstrakta M. alba i njihovog molekularnog mehanizma još uvek je nepoznato. U ogledu su korišćeni laboratorijski beli pacovi (180-200 g) (n=5-6). Kontrolna grupa je intraperitonealno (i.p) dobijala 0.2 ml normalnog fiziološkog rastvora jednom u toku dana tokom dve nedelje. Kontrolnim životinjama je davana standardna hrana. Tretirane grupe su dobijale ili polifenolni ekstrakt (100 mg/kg, i.p) ili glifosat (100 mg/kg, i.p), ili pak njihovu smešu (ekstrakt mg ml-1 kg t.m. i glifosat 100 mg kg-1 t.m, i.p), jednom dnevno do petnaestog dana tretmana. Merene su vrednosti laktat dehidrogenaze LDH, koncentracije uree, kreatitina i azotmonoksida u serumu, a korišćene su standardne kolorometrijske metode. Renalni oksidativni stress, konstatovan preko povišenih vrednosti malondialdehida (MDA) i nivoa proteinskih karbonila, kao i snižene aktivnosti superoksida dismutase (SOD), bio je značajno povišen delovanjem primenjenog ekstrakta lista duda (MLE). MLE je pokazao da može da modulira izmenjene biohemijske parameter održavanjem nivoa slobodnog gvožđa i homeostaze Ca2+, kao i da reguliše endogeni sistem antioksidativnih enzima. Izgleda da istovremena primena vodenog acetonskog rastvora frakcije M. alba koji je bogat hlorogenom kiselinom i njenim izomerima može imati zaštitno delovanje na bubrege nakon nefrotoksične aktivnosti glifosata. Ukupno gledano, MLE može delovati zaštitno protiv toksičnosti indukovane glifosatom, što se može pripisati hlorogenoj kiselini i njenim izomerima, koji predstavljaju najprisutnije fenolne kiseline u ekstraktima. List belog duda je izvor fenolnih jedinjenja i stoga može predstavljati osnovu za potragu za novim hemijskim jedinjenjem koje će omogućiti dobijanje novog lekovitog sredstva. Suplement od ekstrakta belog duda može biti kandidat za razvoj bezbednog i perspektivnog preparata kao dodatka ishrani namenjenog zaštiti od nefrotoksičnosti.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/PIF2101045R
primljen: 25.12.2020.
prihvaćen: 15.03.2021.
objavljen u SCIndeksu: 26.06.2021.
metod recenzije: dvostruko anoniman
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