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2021, vol. 24, br. 94, str. 7-16
Istraživanje dokaza eksaptacije u kliničkim istraživanjima u kreiranju farmaceutskih inovacija
Inventis CTC, Nice, France

e-adresam.stamenovic@rocketmail.com
Ključne reči: eksaptacija; repozicija lekova; farmaceutska industrija; inovacije; farmakoekonomija; istraživanja i razvoj
Sažetak
Eksaptacija je proces koji se odlikuje evolucijom karakteristika artefakta i evolucijom za druge upotrebe koji je kasnije prihvaćen kao njihova nova uloga. U farmaceutskoj industriji inovacije imaju visok potencijal u pogledu konkurentske prednosti i dobiti, ali su takođe povezane sa visokim rizicima povezanim sa troškovima, vremenom i neizvesnošću. Da bi umanjili rizike, kompanije često biraju strategiju eksaptacije u smislu ponovnog razvoja hemijskih jedinjenja za upotrebu kod drugih oboljenja. Namera ovog istraživanja je da pruži analizu i kvantifikaciju (merenje) broja lekova (molekula) koji su "eksaptirani" kroz proces repozicioniranja lekova. Rezultati ukazuju da smo na nivou od 6098 kliničkih studija, faza I, primetili ukupno 659 lekova / supstanci (~ 11%) koji su korišćeni u više kliničkih istraživanja za istu ili različitu indikaciju koja pokazuje nivo upotrebe eksaptacije u kliničkim istraživanjima.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.5937/rev2194007S
primljen: 19.02.2021.
prihvaćen: 21.04.2021.
objavljen u SCIndeksu: 24.12.2021.