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2016, vol. 73, br. 6, str. 531-537
Praksa propisivanja lekova protiv povišenog krvnog pritiska u Novom Sadu i usklađenost sa farmakoterapijskim smernicama
aUniverzitet u Novom Sadu, Medicinski fakultet, Zavod za farmakologiju, toksikologiju i kliničku farmakologiju
bUniverzitet u Novom Sadu, Medicinski fakultet

e-adresaaanaa_tomas@yahoo.com
Projekat:
Interakcije ksenobiotika i uticaj na sisteme u biomedicini (MPNTR - 41012)

Sažetak
Uvod/Cilj. Hipertenzija je jedan od vodećih uzroka kardiovaskularnog morbiditeta i mortaliteta u Srbiji, te više od polovine troškova za lekove na teret osiguranja odlazi na antihipertenzivne lekove. Cilj ove studije bio je analiza strukture upotrebe antihipertenzivnih lekova kod hipertenzivnih vanbolničkih pacijenata u Novom Sadu, usklađenosti sa farmakoterapijskim uputstvima i ekonomskih aspekta trenutne prakse propisivanja. Metode. Podaci o prometu i potrošnji antihipertenzivnih lekova propisanih kod vanbolničkih pacijenata sa dijagnozom esencijalne arterijske hipertenzije u šestomesečnom periodu prikupljeni su u državnim apotekama u Novom Sadu. Lekovi su klasifikovani prema anatomsko-terapijsko-hemijskoj klasifikaciji lekova i izračunate definisane dnevne doze (DID) na hiljadu stanovnika na dan. Rezultati. Ukupna potrošnja antihipertenzivnih lekova izdatih na recept u periodu od šest meseci u Novom Sadu bila je 283,48 DID. Najčešće korištena grupa lekova bili su inhibitori angiotenzin konvertujuceg enzima (ACEi), koji su propisivani tri puta češće od kalcijumskih antagonista i pet puta više od beta blokatora. Iako uputstva za lečenje hipertenzije navode da su svi ACEi jednako efikasni, primećena je upotreba skupljih ACEi. Upotreba diuretika i antagonista receptora angiotenzina bila je niska u posmatranom periodu. Farmakoterapijska uputstva naglašavaju prednost i efikasnost diuretika u lečenju hipertenzije kod starijih osoba, ali njihova potrošnja bila je neopravdano niska, uprkos činjenici da je preko 70% svih antihipertenzivnih lekova u Novom Sadu propisana pacijentima starijim od 60 godina. Zaključak. Ovo ispitivanje pokazalo je velike razlike u propisivanju različitih grupa antihipertenzivnih lekova. Nedovoljno korišćenje tiazidnih diuretika, lekova sa najboljim odnosom koristi i troškova i upotreba skupih ACE inhibitora je neopravdana. Postoji mogućnost za značajne uštede sa racionalnijom upotrebom ACEi, po uzoru na skandinavske zemlje.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/vsp141119047T
objavljen u SCIndeksu: 02.06.2016.
metod recenzije: dvostruko anoniman
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