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Uticaj antihipertenzivne terapije, unosa natrijuma i koncentracije kalijuma u plazmi na koncentraciju aldosterona i plazma reninsku aktivnost
nema
Ključne reči: aldosteron; PRA; lekovi; natrijum; kalijum
Sažetak
Uvod: Primarni aldosteronizam (PA) predstavlja grupu poremećaja koja se odlikuje neadekvatnom i nesupresibilnom produkcijom aldosterona. Prevalenca PA je rastuća u hipertenzivnoj populaciji. Zlatni standard za skrining PA, određivanje odnosa (ARR) aldosterona i plazma reninske aktivnosti (PRA) posturalno, pod uticajem je brojnih endogenih i egzogenih faktora. Testiranje u optimalnim uslovima nije uvek moguće. Cilj rada: Utvrditi kakav je uticaj antihipertenzivnih lekova i koncentracije kalijuma i natrijuma u krvi i urinu na vrednosti aldosterona i plazma reninsku aktivnost. Metod rada: U retrospektivnoj studiji analizirana je medicinska dokumentacija pacijenata primljenih na Odeljenje za bolesti štitaste žlezde u periodu 2009-2011. godine sa povećanim rizikom za primarni aldosteronizam. Kod svih pacijenata analizirani su telesna masa i visina, koncentracije natrijuma i kalijuma u serumu i urinu, koncentracije aldosterona u plazmi i PRA, podaci o lekovima u terapiji i pridruženim bolestima. Od statističkih metoda korišćeni su metodi deskriptivne statistike, Studentov T test i jednostruka linearna povezanost. Rezultati: Od 137 pacijenata bilo je više pacijenata sa rezistentnom hipertenzijom (53,28%) nego sa tumorima nadbubrega (46,72%). Najviše pacijenata bilo je na terapiji kalcijumskim antagonistima. Terapija alfa adrenergičkim i kalcijumskim antagonistima ne utiče na ARR. Blokatori beta adrenergičkih receptora i ACE inhibitori mogu da utiču, a diuretici i vazodilatatori sigurno utiču. Dijabetes melitus može da nosi veći rizik od lažno negativnih rezultata. Natriureza je značajno povezana sa plazma aldosteronom i kalijumom u serumu. Plazma aldosteron i PRA značajno su povezani sa koncentracijama elektrolita u urinu. Zaključak: Povećana prevalenca primarnog aldosteronizma nameće potrebu za preciznijom i boljom dijagnostikom.
Reference
*** (2008) Primary Aldosteronism in Diabetic Subjects With Resistant Hypertension: Response to Ng et al. Diabetes Care, 31: e3
Ahmed, A.H., Gordon, R.D., Taylor, P.J., Ward, G., Pimenta, E., Stowasser, M. (2011) Effect of contraceptives on aldosterone/renin ratio may vary according to the components of contraceptive, renin assay method, and possibly route of administration. Journal of clinical endocrinology and metabolism, 96(6): 1797-804
Ahmed, A.H., Calvird, M., Gordon, R.D., Taylor, P.J., Ward, G., Pimenta, E., Young, R., Stowasser, M. (2011) Effects of two selective serotonin reuptake inhibitor antidepressants, sertraline and escitalopram, on aldosterone/renin ratio in normotensive depressed male patients. Journal of clinical endocrinology and metabolism, 96(4): 1039-45
Ahmed, A.H., Gordon, R.D., Taylor, P.J., Ward, G., Pimenta, E., Stowasser, M. (2011) Are women more at risk of false-positive primary aldosteronism screening and unnecessary suppression testing than men?. Journal of clinical endocrinology and metabolism, 96(2): E340-6
Ahmed, A.H., Gordon, R.D., Taylor, P., Ward, G., Pimenta, E., Stowasser, M. (2010) Effect of atenolol on aldosterone/renin ratio calculated by both plasma Renin activity and direct Renin concentration in healthy male volunteers. Journal of clinical endocrinology and metabolism, 95(7): 3201-6
Al-Mallah, M., Khawaja, O., Sinno, M., Alzohaili, O., Samra, A.A.B. (2010) Do angiotensin converting enzyme inhibitors or angiotensin receptor blockers prevent diabetes mellitus? A meta-analysis. Cardiology journal, 17(5): 448-56
Bochud, M., Nussberger, J., Bovet, P., Maillard, M.R., Elston, R.C., Paccaud, F., Shamlaye, C., Burnier, M. (2006) Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension, 48(2): 239-45
Bourgoignie, J.J., Catanzaro, F.J., Perry, H.M., Schoepfle, E., Kurz, L. (1968) Renin-Angiotensin-Aldosterone System During Chronic Thiazide Therapy of Benign Hypertension. Circulation, 37(1): 27-35
Calhoun, D.A., Jones, D., Textor, S., Goff, D.C., Murphy, T.P., Toto, R.D., White, A., Cushman, W.C., White, W., Sica, D., Ferdinand, K., Giles, T.D., Falkner, B., Carey, R.M. (2008) Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension, 51(6): 1403-1419
Carpenè, G., Rocco, S., Opocher, G., Mantero, F. (1989) Acute and chronic effect of nifedipine in primary aldosteronism. Clinical and experimental hypertension. Part A, Theory and practice, 11(7): 1263-72
Chidambaram, M., Duncan, J.A., Lai, V.S., Cattran, D.C., Floras, J.S., Scholey, J.W., Miller, J.A. (2002) Variation in the renin angiotensin system throughout the normal menstrual cycle. Journal of the American Society of Nephrology, 13(2): 446-52
Clark, 3rd D., Ahmed, M.I., Calhoun, D.A. (2012) Resistant hypertension and aldosterone: an update. Can J Cardiol. Epub, 2012
Fagugli, R.M., Taglioni, C. (2011) Changes in the perceived epidemiology of primary hyperaldosteronism. International journal of hypertension, 2011: 162804
Fiad, T.M., Cunningham, S.K., Hayes, F.J., Mckenna, T.J. (1997) Effects of nifedipine treatment on the renin-angiotensin-aldosterone axis. J Clin Endocrinol Metab, 82(2): 457-460
Fox, C.S., Larson, M.G., Hwang, S., Leip, E.P., Rifai, N., Levy, D., Benjamin, E.J., Murabito, J.M., Meigs, J.B., Vasan, R.S. (2006) Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample. Kidney international, 69(11): 2064-9
Funder, J.W., Carey, R.M., Fardella, C., Gomez-Sanchez, C.E., Mantero, F., Stowasser, M., Young, W.F., Montori, V.M. (2008) Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism, 93(9): 3266-3281
Gaddam, K.K., Nishizaka, M.K., Pratt-Ubunama, M., i dr. (2008) Resistant hypertension characterized by increased aldosterone levels and persistent intravascular volume expansion. Arch Intern Med., 168(11): 1159-1164
Gaddam, K., Corros, C., Pimenta, E., Ahmed, M., Denney, T., Aban, I., Inusah, S., Gupta, H., Lloyd, S.G., Oparil, S., Husain, A., Dell`Italia, L.J., Calhoun, D.A. (2010) Rapid reversal of left ventricular hypertrophy and intracardiac volume overload in patients with resistant hypertension and hyperaldosteronism: a prospective clinical study. Hypertension, 55(5): 1137-42
Gu, Q. (2006) Antihypertensive Medication Use Among US Adults With Hypertension. Circulation, 113(2): 213-221
Haller, H., Ito, S., Izzo, J.L., Januszewicz, A., Katayama, S., Menne, J., Mimran, A., Rabelink, T.J., Ritz, E., Ruilope, L.M., Rump, L.C., Viberti, G. (2011) Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. New England journal of medicine, 364(10): 907-17
Hannemann, A., Bidlingmaier, M., Friedrich, N., Manolopoulou, J., Spyroglou, A., Völzke, H., Beuschlein, F., Seissler, J., Rettig, R., Felix, S.B., Biffar, R., Döring, A., Meisinger, C., Peters, A., Wichmann, H.E., Nauck, M., Wallaschofski, H., Reincke, M. (2012) Screening for primary aldosteronism in hypertensive subjects: results from two German epidemiological studies. European journal of endocrinology, 167(1): 7-15
Hollenberg, N.K., Stevanovic, R., Agarwal, A., Lansang, C.M., Price, D.A., Laffel, L.M.B., Williams, G.H., Fisher, N.D.L. (2004) Plasma aldosterone concentration in the patient with diabetes mellitus Rapid Communication. Kidney International, 65(4): 1435-1439
Jürgens, G., Graudal, N.A. (2004) Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride. Cochrane Database Syst Rev, (1):CD004022
Kathiresan, S., Larson, M.G., Benjamin, E.J., Corey, D., Murabito, J.M., Fox, C.S., Wilson, P.W.F., Rifai, N., Meigs, J.B., Ricken, G., Lifton, R.P., Levy, D., Vasan, R.S. (2005) Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study. American journal of hypertension, 18(5 Pt 1): 657-65
Kondo, T., Goto, R., Sonoda, K., Yasuda, T., Ono, K., Takaki, Y., Yatsuda, R., Miyamura, N., Araki, E. (2010) Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine, in hypertensive patients. Internal Medicine, 49(7): 637-43
Kronenberg, H.M., Melmed, S., Polonsky, K.S., Larsen, P.R. (2008) Williams textbook of endocrinology. Philadelphia: Saunders Elsevier
Lijnen, P., Fagard, R., Staessen, J., Amery, A. (1981) Effect of chronic diuretic treatment on the plasma renin-angiotensin- aldosterone system in essential hypertension. British Journal of Clinical Pharmacology, 12(3): 387-392
Lőcsei, Z., Horváth, D., Rácz, K., Szabolcs, I., Kovács, G.L., Toldy, E. (2012) Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio. Clinical Biochemistry, 45(16-17): 1516-1518
Luik, P.T., Kerstens, M.N., Hoogenberg, K., Navis, G.J., Dullaart, R.P.F. (2003) Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes mellitus: effects of RAAS stimulation. European Journal of Clinical Investigation, 33(9): 787-793
McFarlane, S.I., Sowers, J.R. (2003) Aldosterone Function in Diabetes Mellitus: Effects on Cardiovascular and Renal Disease. Journal of Clinical Endocrinology & Metabolism, 88(2): 516-523
Miller, J.A., i dr. (2006) Gender Differences in the Renal Response to Renin-Angiotensin System Blockade. Journal of the American Society of Nephrology, 17(9): 2554-2560
Miller, J.A., Anacta, L.A., Cattran, D.C. (1999) Impact of gender on the renal response to angiotensin II. Kidney International, 55(1): 278-285
Mukherjee, J.J., Khoo, C.M., Thai, A.C., Chionh, S.B., Pin, L., Lee, K.O. (2010) Type 2 diabetic patients with resistant hypertension should be screened for primary aldosteronism. Diabetes and Vascular Disease Research, 7(1): 6-13
National Institutes of Health (2002) State of the science conference statement: Management of the clinically inapparent adrenal mass (incidentaloma). February 4-6
Nawar, R., Aron, D. (2005) Adrenal incidentalomas -- a continuing management dilemma. Endocrine-related cancer, 12(3): 585-98
Ng, Y.W., Tiu, S.C., Ng, J.C.M., Chan, H.Y. (2008) Primary aldosteronism in diabetic subjects with resistant hypertension: response to Umpierrez et al. Diabetes care, 31(1): e2; author reply e3
Olivieri, O., Ciacciarelli, A., Signorelli, D., Pizzolo, F., Guarini, P., Pavan, C., Corgnati, A., Falcone, S., Corrocher, R., Micchi, A., Cressoni, C., Blengio, G. (2004) Aldosterone to Renin ratio in a primary care setting: the Bussolengo study. Journal of clinical endocrinology and metabolism, 89(9): 4221-6
Perciaccante, A., Fiorentini, A., Valente, R., di Stefano, A., Tubani, L. (2007) Insulin Resistance and Hyperinsulinemia Are Related to Plasma Aldosterone Levels in Hypertensive Patients: Response to Colussi et al. Diabetes Care, 30(10): e106-e106
Pratt, J.H., Grim, C.E., Parkinson, C.A. (1980) Effects of propranolol on aldosterone plasma concentration and aldosterone metabolic clearance in hypertensive patients. J Lab Clin Med., 95(5): 693-697
Richards, A.M., Nicholls, M.G., Espiner, E.A., Ikram, H., Hamilton, E.J., Wells, J.E., Maslowski, A.H., Yandle, T.G. (1985) Endogenous angiotensin-aldosterone-pressure relationships during sodium restriction. Hypertension, 7(5): 681-7
Ritz, E., Schmieder, R.E., Pollock, C.A. (2010) Renal protection in diabetes: lessons from ONTARGET. Cardiovascular diabetology, 9: 60
Rossi, G.P., Belfiore, A., Bernini, G., i dr. (2008) Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. J Clin Endocrinol Metab., Epub
Schirpenbach, C., Reincke, M. (2006) Screening for primary aldosteronism. Best Practice & Research Clinical Endocrinology & Metabolism, 20(3): 369-384
Schrier, R. W., Masoumi, A., Elhassan, E. (2010) Aldosterone: Role in Edematous Disorders, Hypertension, Chronic Renal Failure, and Metabolic Syndrome. Clinical Journal of the American Society of Nephrology, 5(6): 1132-1140
Schunkert, H., Danser, A.H., Hense, H.W., Derkx, F.H., Kürzinger, S., Riegger, G.A. (1997) Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women. Circulation, 95(1): 39-45
Smiley, D., Umpierrez, G., i dr. (2007) Primary Aldosteronism among diabetic patients with resistant hypertension. Journal Watch, July, (General), 26, 5
Sullivan, J.C. (2008) Sex and the renin-angiotensin system: Inequality between the sexes in response to RAS stimulation and inhibition. Regulatory, Integrative and Comparative Physiology, February 20
Tarazi, R.C., Dustan, H.P., Frohlich, E.D. (1970) Long-Term Thiazide Therapy in Essential Hypertension: Evidence for Persistent Alteration in Plasma Volume and Renin Activity. Circulation, 41(4): 709-717
Umpierrez, G.E., Cantey, P., Smiley, D., Palacio, A., Temponi, D., Luster, K., Chapman, A. (2007) Primary Aldosteronism in Diabetic Subjects With Resistant Hypertension. Diabetes Care, 30(7): 1699-1703
Walker, W.G., Whelton, P.K., Saito, H., Russell, R.P., Hermann, J. (1979) Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension, 1(3): 287-91
Weidmann, P., de Myttenaere-Bursztein, S., Maxwell, M.H., de Lima, J. (1975) Effect on aging on plasma renin and aldosterone in normal man. Kidney international, 8(5): 325-33
Whaley-Connell, A., Sowers, J.R. (2011) Aldosterone and Risk for Insulin Resistance. Hypertension, 58(6): 998-1000
Xun, P., Liu, K., Cao, W., Sidney, S., Williams, D.O., He, K. (2012) Fasting insulin level is positively associated with incidence of hypertension among American young adults: a 20-year follow-up study. Diabetes care, 35(7): 1532-7
 

O članku

jezik rada: srpski, engleski
vrsta rada: neklasifikovan
DOI: 10.5937/medgla1348044L
objavljen u SCIndeksu: 09.09.2013.

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