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2022, vol. 11, br. 1, str. 22-31
Valorizacija ulja semena šljive za razvoj topikalne formulacije
aUniverzitet u Nišu, Tehnološki fakultet, Leskovac
bChemical-Technological High School 'Bozidar Djordjevic Kukar', Leskovac

e-adresasavicivana@tf.ni.ac.rs, savicivana@tf.ni.ac.rs
Projekat:
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (institucija: Univerzitet u Nišu, Tehnološki fakultet, Leskovac) (MPNTR - 451-03-68/2020-14/200133)

Ključne reči: formulacija/stabilnost; emulzija; antioksidativna aktivnost; kontrola kvaliteta
Sažetak
Cilj ovog rada bio je da se upotrebi ulje semena šljive za pripremu topikalne formulacije za negu kože, s obzirom da ono može da poboljša elastičnost i spreči ubrzano starenje kože. Soxhlet ekstrakcija korišćena je za izolaciju ulja semena šljive primenom n-heptana. Spektrofotometrijske metode su korišćene za određivanje fotoprotektivnog efekta i antioksidativne aktivnosti uzoraka. Toplo-toplo emulzifikacioni proces korišćen je za izradu topikalne formulacije na bazi ulja semena šljive. Antioksidativna aktivnost ulja semena šljive procenjena je na osnovu polovine maksimalne inhibitorne koncentracije (IC50 = 9,39 mg/mL). Nakon ugradnje ulja, IC50 vrednost od 9,33 mg/mL nije bila značajno promenjena. Viskozitet topikalne formulacije i ulja semena šljive bio je 1,56×106 mPa·s (pri brzini smicanja 5 s-1) i 60,48 mPa·s (pri brzini smicanja 50 s-1), respektivno. Reološka analiza pokazala je da su ulje semena šljive i topikalna formulacija Njutnovski i nenjutnovski pseudoplastični fluidi, respektivno. Formulacija apsorbuje svetlost u UV-Vis oblasti tako da se može koristiti kao v/u emulzioni fotozaštitni krem. Krem sa adekvatnom pH vrednošću bila je stabilna i mikrobiološki bezbedna za primenu na koži. Zbog upotrebe jeftinijih sastojaka, formulacija je prihvatljiva i pogodna za proizvodnju.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.5937/savteh2201022S
primljen: 18.03.2022.
prihvaćen: 29.05.2022.
objavljen u SCIndeksu: 14.07.2022.

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