Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:2
  • preuzimanja u poslednjih 30 dana:0

Sadržaj

članak: 4 od 8  
Back povratak na rezultate
2010, vol. 7, br. 1, str. 16-21
Homeostaza energije i fiziologija njene regulacije
Institut za fiziologiju i antropologiju, Medicinski fakultet, Skopje, Makedonija

e-adresasani_960@ yahoo.com
Ključne reči: homeostaza energije; fiziologija; hipotalamus; hormoni; neuropeptidi
Sažetak
Poznavanje regulacije unosa hrane je od ključnog značaja za razumevanje fizioloških mehanizama uključenih u regulaciju telesne težine i pojavu gojaznosti. Sposobnost organizma da efikasno skladišti energiju hrane u vidu masti obezbeđuje opstanak kada je snabdevanje hranom oskudno ili sporadično. Da bi održali takve rezerve hrane, bez posledične kontinuirane promene u njihovoj veličini i obliku, regulatorni sistemi balansiraju kalorijski unos i energetsku potrošnju koliko je potrebno. Sasvim je jasno da telo ima veoma složen i sofisticiran sistem za regulisanje energetskog bilansa i rezerva masti. Biologija ovog sistema je tek na početku našeg razumevanja, ali delovi slagalice se postavljaju na svoje mesto. Neki od ovih mehanizama su analizirani u ovom preglednom radu. Uloga perifernih signala iz masnog tkiva, pankreasa i gastrointestinalnog trakta koji održavaju kratkotrajnu i dugotrajnu uhranjenost su ovde opisani. Takvi signali utiču na centralne projekcije u hipotalamusu, moždanom stablu i limbičkom sistemu i moduliraju oslobađanje neuropeptida i stoga unos hrane i potrošnju energije. Ovaj pregled razmatra periferne hormone i centralne neuronske projekcije koji učestvuju u kontroli homeostaze energije.
Reference
Arosio, M., Ronchi, C.L., Gebbia, C., Cappiello, V., Beck-Peccoz, P., Peracchi, M. (2003) Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels. Journal of clinical endocrinology and metabolism, 88(2): 701-4
Asakawa, A., Inui, A., Yuzuriha, H., Ueno, N., Katsuura, G., Fujimiya, M., Fujino, M.A., Niijima, A., Meguid, M.M., Kasuga, M. (2003) Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology, 124(5): 1325-36
Batterham, R.L., Cowley, M.A., Small, C.J., Herzog, H., Cohen, M.A., Dakin, C.L., Wren, A.M., Brynes, A.E., Low, M.J., Ghatei, M.A., Cone, R.D., Bloom, S.R. (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature, 418(6898): 650-4
Benoit, S.C., Schwartz, M.W., Lachey, J.L., Hagan, M.M., Rushing, P.A., Blake, K.A., Yagaloff, K.A., Kurylko, G., Franco, L., Danhoo, W., Seeley, R.J. (2000) A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. Journal of neuroscience, 20(9): 3442-8
Benoit, S.C., Air, E.L., Coolen, L.M., Strauss, R., Jackman, A., Clegg, D.J., Seeley, R.J., Woods, S.C. (2002) The catabolic action of insulin in the brain is mediated by melanocortins. Journal of neuroscience, 22(20): 9048-52
Chen, H.Y., Trumbauer, M.E., Chen, A.S., Weingarth, D.T., Adams, J.R., Frazier, E.G., Shen, Z., Marsh, D.J., Feighner, S.D., Guan, X.M., Ye, Z., Nargund, R.P., Smith, R.G., van Ploeg, L.H.T., Howard, A.D., MacNeil, D.J., Qian, S. (2004) Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology, 145(6): 2607-12
Dakin, C.L., Gunn, I., Small, C.J., Edwards, C.M., Hay, D.L., Smith, D.M., Ghatei, M.A., Bloom, S.R. (2001) Oxyntomodulin inhibits food intake in the rat. Endocrinology, 142(10): 4244-50
Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M.S., Suganuma, T., Matsukura, S., Kangawa, K., Nakazato, M. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology, 141(11): 4255-61
Đukić, A., Đurđević, P., Mladenović, V., Živancević-Simonović, S. (2005) The effect of repaglinide on the first phase of insulin secretion in persons with impaired glucose homeostasis. Medical Journal, 1, str. 7-12
Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B., Elmquist, J.K. (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron, 23(4): 775-86
Fu-Cheng, X., Anini, Y., Chariot, J., Castex, N., Galmiche, J.P., Rozé, C. (1997) Mechanisms of peptide YY release induced by an intraduodenal meal in rats: neural regulation by proximal gut. Pflügers Archiv, 433(5): 571-9
Ge, H., Huang, L., Pourbahrami, T., Li, C. (2002) Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. Journal of biological chemistry, 277(48): 45898-903
Harrold, J.A., Widdowson, P.S., Williams, G. (1999) Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Diabetes, 48(2): 267-71
Holst, J. (1999) Glucagon-like peptide 1 (GLP-1): an intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential. Trends in Endocrinology and Metabolism, 10(6): 229-235
Kissileff, H.R., Carretta, J.C., Geliebter, A., Pi-Sunyer, X.F. (2003) Cholecystokinin and stomach distension combine to reduce food intake in humans. American journal of physiology. Regulatory, integrative and comparative physiology, 285(5): R992-8
Larhammar, D. (1996) Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept, 65(3): 165-74
Marks, J.L., Porte, D., Stahl, W.L., Baskin, D.G. (1990) Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology, 127(6): 3234-6
Menéndez, J.A., Atrens, D.M. (1991) Insulin and the paraventricular hypothalamus: modulation of energy balance. Brain research, 555(2): 193-201
Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., Sewter, C.P., Digby, J.E., Mohammed, S.N., Hurst, J.A., Cheetham, C.H., Earley, A.R., Barnett, A.H., Prins, J.B., O'Rahilly, S. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, 387(6636): 903-8
Reeve, J.R., Eysselein, V.E., Ho, F.J., Chew, P., Vigna, S.R., Liddle, R.A., Evans, C. (1994) Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology. Annals of the New York Academy of Sciences, 713: 11-21
Stanley, B.G., Kyrkouli, S.E., Lampert, S., Leibowitz, S.F. (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides, 7(6): 1189-92
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N.H. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423(6941): 762-9
 

O članku

jezik rada: engleski
vrsta rada: pregledni članak
objavljen u SCIndeksu: 08.04.2011.

Povezani članci