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Serbian Journal of Experimental and Clinical Research
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Cardiovascular adipobiology: A novel - Heart-associated adipose tissue in cardiovascular disease
(naslov ne postoji na srpskom)
Medical University, Varna, Bulgaria

e-adresachaldakov@yahoo.com
Ključne reči: adipokines; atherosclerosis; epicarial adipose tissue; neurotrophic factors; neuropeptides; periadventitial adipose tissue
Sažetak
(ne postoji na srpskom)
This article provides a conceptual framework for the possible role of (i) periadventitial adipose tissue, and (ii) epicardial adipose tissue in the pathogenesis of cardiovascular disease. Traditional concepts of atherogenesis are focused on luminal surface, where 'inside-out' inflammatory events trigger the extravasation of immune cells and the accumulation of lipids, smooth muscle cells and matrix components leading to atherosclerotic plaque formation. However, increasing evidence supports a new concept of an 'outside-in' responses, involving periadventitial adipose tissue, herein referred to as tunica adiposa, and epicardial adipose tissue, these two adipose loci functioning as secretory tissues. Thus, a paracrine signals originated from these tissues could be transmitted into both the coronary artery intima and the myocardium. The present review highlights the possibility for tunica adiposa and epicardial adipose tissue to play an important role in an 'outside-in' signaling in the development of atherosclerosis and cardiomyopathy. In effect, adipose-targeted pharmacology and noninvasive measures might provide novel clinical insights into cardiovascular adipobiology. Data of adipose-derived adipokines, including neurotrophic factors and neuropeptides, are also presented, raising a hypothesis of neuroendocrine potential of adipose tissue; it may also be instrumental in the pathogenesis of cardiovascular disease.
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O članku

jezik rada: engleski
vrsta rada: uvodnik
objavljen u SCIndeksu: 14.01.2009.

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