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2021, vol. 62, br. 1, str. 1-14
Ekstrakt crnog luka bogat alicinom ublažava komplikacije izazvane visokomasnom ishranom kod pacova - nutrigenomska studija
aTR(i)P for Health Laboratory, Centre of Excellence in Functional Foods, Department of Food and Nutritional Biotechnology, National Agri-food Biotechnology Institute (NABI), SAS Nagar, India + Regional Centre for Biotechnology, Faridabad-Gurgaon expressway, Faridabad, India
bTR(i)P for Health Laboratory, Centre of Excellence in Functional Foods, Department of Food and Nutritional Biotechnology, National Agri-food Biotechnology Institute (NABI), SAS Nagar, India + Panjab University, Department of Biotechnology, Chandigarh, India
cFriedrichAlexander-Universität, UniClinic, Department of Anesthesiology, Erlangen-Nürnberg, Germany
dNational Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmacology and Toxicology, SAS Nagar, India
eNational Institute of Pharmaceutical Education and Research (NIPER), Department of Natural Products, SAS Nagar, India
fTR(i)P for Health Laboratory, Centre of Excellence in Functional Foods, Department of Food and Nutritional Biotechnology, National Agri-food Biotechnology Institute (NABI), SAS Nagar, India + Panjab University, University Institute of Pharmaceutical Sciences (UIPS), Pharmacology Division, Chandigarh, India
gTR(i)P for Health Laboratory, Centre of Excellence in Functional Foods, Department of Food and Nutritional Biotechnology, National Agri-food Biotechnology Institute (NABI), SAS Nagar, India

e-adresambishnoi@nabi.res.in
Projekat:
Authors would like to thank Department of Biotechnology (DBT), Government of India for providing research grant to National Agri-food Biotechnology Institute (NABI) and Dr. Mahendra Bishnoi, research fellowship to Ms. Neha Mahajan. Authors would like to thank DBTeLibrary Consortium (DelCON) for providing online literature resources.

Ključne reči: ARGE, ekstrakt crnog luka bogat alicinom; TRPA1; gojaznost; mrko masno tkivo; belo masno tkivo; dialil disulfidi; dialil trisulfidi; insulinska rezistencija; WAT browning; hormoni creva
Sažetak
Lekovito dejstvo crnog luka pri različitim metaboličkim komplikacijama pripisuje se raznovrsnim organskim sumpornim jedinjenjima, kao što su alicin, dialil sulfidi, aliin i alil trisulfidi. U ovoj studiji izolovani su vodeni ekstrakti crnog luka sa stabilnim alicinom i ispitivani njihovi biološki tkivno specifični nutrigenomski efekti u sprečavanju gojaznosti i povezanih komplikacija izazvanih visokomasnom ishranom (HFD) u Sprague-Dawley (SD) pacovima. Pripremljen je rastvor ekstrakta crnog luka bogat alicinom (ARGE), a stabilnost alicina okarakterisana je HPLC metodom. Za biološku evaluaciju životinje su hranjene 16 nedelja normalnom hranom, visokomasnom hranom, visokomasnom hranom zajedno sa ARGE (1ml/kg p.o.) ili samim ARGE (1ml/kg p.o.). Hronična administracija ARGE sprečila je gojenje izazvano visokomasnom ishranom, hipertrofi ju masnog tkiva, insulinsku rezistenciju i generalno je dovela do poboljšanja glukozne homeostaze. Transkripciona analiza različitih tkiva pre svega je pokazala da ARGE promoviše browning, pospešuje glukozni metabolizam i regulaciju apetita. Ova studija pokazuje da ARGE ima nutraceutski potencijal u prevenciji gojaznosti i povezanih komorbiditeta.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.5937/hraIsh2101001M
objavljen u SCIndeksu: 28.12.2021.