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2023, vol. 73, br. 2, str. 146-171
Upravljanje resursima u HPLC - otkrivanje zelenog lica farmaceutske analize
Univerzitet u Beogradu, Farmaceutski fakultet, Institut za farmaceutsku hemiju i analitiku lekova, Srbija

e-adresajstojanovic@pharmacy.bg.ac.rs
Ključne reči: tečna hromatografija visokih performansi; procena ekološke prihvatljivosti metoda; održivost
Sažetak
Tečna hromatografija pod visokim pritiskom (HPLC) je tehnika od ogromne važnosti u analitici lekova zbog svoje mogućnosti da razdvoji umereno do manje polarna jedinjenja, kao što su aktivne farmaceutske i srodne supstance. Koncept zelene analitičke hemije (GAC) ima za cilj da obezbedi ekološki prihvatljivije i bezbednije metode u pogledu reagenasa, energije i otpada. Jedan od glavnih izazova GAC je da pronađe odgovarajući pristup za procenu "zelenosti" analitičkih metoda. Proširenje GAC, nazvano bela analitička hemija (WAC), uvedeno je kako bi se uzela u obzir ne samo ekološka prihvatljivost, već i drugi aspekti koji doprinose održivosti metoda, kao što su analitička i ekonomska ili praktična efikasnost. HPLC metode suštinski nisu "zelene" zbog obimne potrošnje toksičnih organskih rastvarača i posledičnog stvaranja velikih količina toksičnog otpada. Srećom, postoji mnogo pristupa za prevazilaženje ne-zelene prirode HPLC metoda. U ovom radu su predstavljene različite modifikacije HPLC metode koje povećavaju ekološku prihvatljivost, kao i različiti alati koji se koriste za procenu ekološke prihvatljivosti. Pored toga, predstavljen je novi koncept bele analitičke hemije.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/arhfarm73-43479
objavljen u SCIndeksu: 06.05.2023.
metod recenzije: jednostruko anoniman
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