Metrika

  • citati u SCIndeksu: [2]
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:6
  • preuzimanja u poslednjih 30 dana:1

Sadržaj

članak: 4 od 4  
Back povratak na rezultate
2010, vol. 29, br. 1, str. 34-38
Promene nivoa grelina kod crevnih parazitskih infekcija
aDepartment of Microbiology, School of Medicine, Firat University, Elazig, Turkey
bDepartment of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Elazig, Turkey
cDepartment of Biology, Faculty of Science, Firat University, Elazig, Turkey

e-adresaaerensoy@yahoo.com
Ključne reči: serum; aktivni/neaktivni grelin; paraoksonaza; arilesteraza; paraziti
Sažetak
Cilj studije bio je da se ispita odnos između aktivnog (aciliranog) i neaktivnog (deaciliranog) grelina u serumu i drugih serumskih parametara kod crevnih parazitskih infekcija i zdravih kontrola. Uobičajene mikroskopske metode (slani rastvor i rastvor joda, trihromatski otisak) korišćene su za identifikaciju crevnih parazita u uzorcima stolice 29 pacijenata Univerzitetske bolnice Firat. Serumski parametri određeni su u jednokratnom merenju seruma 29 pacijenata s parazitima i 18 zdravih kontrolnih subjekata. Nivoi aciliranog grelina i deaciliranog grelina u serumu izmereni su metodom radioimunoeseja. Paraoksonaza i arilesteraza su merene spektrofotometrijski na 405 nm i 270 nm. Koncentracije aciliranog i deaciliranog grelina u serumu bile su upadljivo niže kod pacijenata sa parazitima nego u kontrolnoj grupi. Nivoi glukoze, holesterola i triglicerida bili su viši kod crevnih parazitskih infekcija nego kod kontrola. Štaviše, nije bilo korelacija između nivoa grelina i indeksa telesne mase. Rezultati ukazuju na to da bi niski nivoi grelina i PON1/AE mogli biti važni za praćenje apetita kod crevnih parazitskih infekcija.
Reference
Adelekan, D.A., Thurnham, D.I., Adekile, A.D. (1989) Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease. European journal of clinical nutrition, 43(9): 609-14
Ashraf, A., Mick, G., Meleth, S., Wang, X., McCormick, K. (2007) Insulin treatment reduces pre-prandial plasma ghrelin concentrations in children with type 1 diabetes. Med Sci Monit, 13: CR533-7
Aydin, S., Guzel, S.P., Kumru, S., Aydin, S., Akin, O., Kavak, E., Sahin, I., Bozkurt, M., Halifeoglu, I. (2008) Serum leptin and ghrelin concentrations of maternal serum, arterial and venous cord blood in healthy and preeclamptic pregnant women. Journal of physiology and biochemistry, 64(1): 51-9
Carlini, V.P., Monzon, M.E., Varas, M.M., Cragnolini, A.B., Schioth, H.B., Scimonelli, T.N., Barioglio, S.R. (2002) Ghrelin increases anxiety-like behavior and memory retention in rats. Biochemical and biophysical research communications, 299(5): 739-43
Cummings, D.E., Weigle, D.S., Frayo, S.R., Breen, P.A., Ma, M.K., Dellinger, P.E., Purnell, J.Q. (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New England journal of medicine, 346(21): 1623-30
de Vriese, C., Hacquebard, M., Gregoire, F., Carpentier, Y., Delporte, C. (2007) Ghrelin interacts with human plasma lipoproteins. Endocrinology, 148(5): 2355-62
Eckerson, H.W., Wyte, C.M., la du Bert, N. (1983) The human serum paraoxonase/arylesterase polymorphism. American Journal of Human Genetics, 35(6), 1126-38
Fujino, K., Inui, A., Asakawa, A., Kihara, N., Fujimura, M., Fujimiya, M. (2003) Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. Journal of physiology, 550(Pt 1): 227-40
Furlong, C.E., Richter, R.J., Seidel, S.L., Motulsky, A.G. (1988) Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon. American journal of human genetics, 43(3): 230-8
Haagen, L., Brock, A. (1992) A new automated method for phenotyping arylesterase (EC 31.1.2) based upon inhibition of enzymic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. European Journal of Clinical Chemistry and Clinical Biochemistry, 30(7), 391-5
Hong, S.H., Song, J., Min, W.K., Kim, J.Q. (2001) Genetic variations of the paraoxonase gene in patients with coronary artery disease. Clinical biochemistry, 34(6): 475-81
Horoz, M., Aslan, M., Selek, S., Koylu, A.O., Bolukbas, C., Bolukbas, F.F., Celik, H., Erel, O. (2007) PON1 status in haemodialysis patients and the impact of hepatitis C infection. Clinical biochemistry, 40(9-10): 609-14
Hosoda, H., Kojima, M., Matsuo, H., Kangawa, K. (2000) Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochemical and biophysical research communications, 279(3): 909-13
Hosoda, H., Kojima, M., Mizushima, T., Shimizu, S., Kangawa, K. (2003) Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. Journal of biological chemistry, 278(1): 64-70
Inui, A. (2001) Ghrelin: An orexigenic and somatotrophic signal from the stomach. Nature Reviews Neuroscience, 2 551-560
Kılıç, E., Yazar, S., Saraymen, R. (2003) Lipid peroxidation level in patients with blastocystosis. Inönü Üniversitesi Tıp Fakültesi Dergisi, 10: 1-3
Kılıç, E., Yazar, S., Saraymen, R., Özbilge, H. (2004) Serum lipid peroxidation level in patients with taeniasis saginata. Türkiye Parazitoloji Dergisi, 2: 91-3
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762): 656-60
Kojima, M., Kangawa, K. (2002) Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract. Current opinion in pharmacology, 2(6): 665-8
Kumru, S., Aydin, S., Gursu, M.F., Ozcan, Z. (2004) Changes of serum paraoxonase (an HDL-cholesterol-associated lipophilic antioxidant) and arylesterase activities in severe preeclamptic women. Eur J Obstet Gynecol Reprod Biol, 114: 17781
Mackness, B., Durrington, P.N., Mackness, M.I. (1998) Human serum paraoxonase. General pharmacology, 31(3): 329-36
Mackness, M.I., Arrol, S., Abbott, C., Durrington, P.N. (1993) Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis, 104(1-2): 129-35
Marsillach, J., Camps, J., Ferré, N., Beltran, R., Rull, A., Mackness, B., i dr. (2009) Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. BMC Gastroenterol, 14: 9: 3
Nagaya, N., Kangawa, K. (2003) Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure. Current opinion in pharmacology, 3(2): 146-51
Ng, C.J., Wadleigh, D.J., Gangopadhyay, A., Hama, S., Grijalva, V.R., Navab, M., Fogelman, A.M., Reddy, S.T. (2001) Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. Journal of biological chemistry, 276(48): 44444-9
Primo-Parmo, S.L., Sorenson, R.C., Teiber, J., la Du, B.N. (1996) The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics, 33(3): 498-507
Toshinai, K., Mondal, M.S., Nakazato, M., Date, Y., Murakami, N., Kojima, M., Kangawa, K., Matsukura, S. (2001) Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochemical and biophysical research communications, 281(5): 1220-5
Tsuzura, S., Ikeda, Y., Suehiro, T., Ota, K., Osaki, F., Arii, K., Kumon, Y., Hashimoto, K. (2004) Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes. Metabolism: clinical and experimental, 53(3): 297-302
World Health Organization (2005) The evidence is in: Deworming helps meet the Millennium Development Goals. WHO/CDS/ CPE/PVC/2005.12
Yoshimoto, A., Mori, K., Sugawara, A., Mukoyama, M., Yahata, K., Suganami, T., Takaya, K., Hosoda, H., Kojima, M., Kangawa, K., Nakao, K. (2002) Plasma ghrelin and desacyl ghrelin concentrations in renal failure. Journal of the American Society of Nephrology, 13(11): 2748-52
 

O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2478/v10011-010-0004-0
objavljen u SCIndeksu: 03.06.2010.