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2021, vol. 72, br. 4, str. 51-58
Ispitivanje uticaja polimorfizma -318C/T (RS5742909) CTLA4 gena na funkciju bubrega nakon transplantacije
aUniverzitet u Beogradu, Medicinski fakultet
bUniverzitet u Beogradu, Medicinski fakultet + Univerzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju

e-adresaveljancicn16@gmail.com
Ključne reči: CTLA4; polimorfizam; akutno odbacivanje; odložena funkcija kalema
Sažetak
Uvod: Antigen 4 koji je udružen sa citotoksičnim T-limfocitima (engl. Cytotoxic T Lymphocyte Antigen-4, CTLA-4) je molekul koji ima značajnu ulogu u održavanju imunološke homeostaze. U dosadašnjim istraživanjima studije su nedvosmisleno pokazale negativnu ulogu CTLA-4 u aktivaciji T-ćelija. U strukturi gena koji kodira CTLA-4 pronađeni su polimorfizmi u okviru jednog nukleotida (engl. Single Nucleotide Polymorphisms, SNPs) koji bi potencijalno mogli da mijenjaju aktivnost gena a posljedično i proteinsku strukturu. Data genetička varijabilnost se dovodi u vezu sa akutnim odbacivanjem i odloženom funkcijom kalema kao bitnim pokazateljima uspješnosti transplantacije bubrega. Cilj: Cilj studije je ispitivanje povezanosti -318C/T polimorfizma (rs5742909) u genu CTLA4 i akutnog odbacivanja, odnosno odložene funkcije kalema kod pacijenata sa transplantiranim bubregom. Materijal i metode: Ova studija presjeka obuhvatila je 151 ispitanika. Lančanom reakcijom polimerizacije u realnom vremenu (RT-PCR), baziranom na TaqMan metodi, utvrđen je genotip ispitanika koji je dalje analiziran u odnosu na podatke o akutnom odbacivanju i odloženoj funkciji kalema Pirsonovim Hi-kvadrat testom i Fišerovim testom tačne vjerovatnoće. Rezultati: Kod 151 ispitanika najčešći je CC genotip (80,8%), zatim CT (17,9%) i TT (1,3%). Alel C ima učestalost 89,7%, a T-alel 10,3%. Nije pronađena statistički značajna razlika u distribuciji CTLA4 genotipova i alela, kao ni njihova povezanost sa akutnim odbacivanjem i odloženom funkcijom kalema. Ispitivanje povezanosti nosilaca C-, odnosno T-alela i navedenih posttransplantacionih komplikacija takođe nije pokazalo statistički značajnu razliku. Zaključak: U ovom istraživanju nije pronađena statistički značajna povezanost -318C/T (rs5742909) CTLA4 polimorfizma sa akutnim odbacivanjem i odloženom funkcijom kalema nakon transplantacije.
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O članku

jezik rada: srpski
vrsta rada: originalan članak
DOI: 10.5937/mp72-32455
objavljen u SCIndeksu: 21.01.2022.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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