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Journal of Medical Biochemistry
2020, vol. 39, br. 1, str. 91-99
Uticaj NLRP3 i CARD8 polimorfizama na bolesti u vezi sa azbestom
Franko Alenkaa, Goricar Katjab, Kovac Viljemc, Dodic-Fikfak Metodaa, Dolzan Vitab
aUniversity Medical Centre Ljubljana, Clinical Institute of Occupational Medicine, Ljubljana, Slovenia
bUniversity of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia
cInstitute of Oncology Ljubljana, Ljubljana, Slovenia
Projekat:
This work was financially supported by the Slovenian Research Agency (ARRS Grants No. P1-0170, L3-8203)

Ključne reči: inflamazom; polimorfizam; azbestoza; pleuralni plakovi; maligni mezoteliom
Sažetak
Uvod: Cilj ovog istraživanja bio je da se ispita povezanost između polimorfizama NLRP3 rs35829419 i CARD8 rs2043211 i rizika od razvoja pleuralnih plakova, azbestoze i malignog mezotelioma (MM) i da se prouči uticaj interakcija između polimorfizama i izloženosti azbestu na rizik od razvoja ovih bolesti. Metode: Ova studija slučaja je uključivala 416 ispitanika sa pleuralnim plakovima, 160 pacijenata sa azbestozom, 154 ispitanika sa MM i 149 ispitanika bez azbestne bolesti. Polimorfizmi NLRP3 rs35829419 i CARD8 rs2043211 su određivani pomoću metoda zasnovanih na PCR u realnom vremenu. U statističkoj analizi, standardnu deskriptivnu statistiku pratilo je univarijantno i multivarijantno logističko regresiono modeliranje. Rezultati: Izloženost azbestu (srednja i visoka u odnosu na nisku) bila je povezana sa rizikom za svaku proučavanu bolest povezanu sa azbestom. Povećan rizik od pleuralnih plakova je ustanovljen za CARD8 rs2043211 at + TT genotipove (OR = 1,48, 95% CI 1,01-2,16, p = 0,042). Kada je obavljena analiza za pacijente sa MM, kao i za pacijente sa pleuralnim plakovima kao kontrolne slučajeve, primećen je smanjeni MM rizik za nosioce CARD8 rs2043211 TT genotipa (OR = 0,52, 95% CI 0,27-1,00, p = 0,049). Interakcije između genotipova NLRP3 rs35829419 i CARD8 rs2043211 nisu uticale na rizik od bilo koje bolesti povezane sa azbestom. Međutim, kada su testirane interakcije sa izloženošću azbestu, ustanovljen je smanjen rizik od azbestoze za NLRP3 CA + AA genotipove (OR = 0,09, 95% CI 0,01-0,60, p = 0,014). Zaključak: Rezultati našeg istraživanja ukazuju na to da polimorfizmi NLRP3 i CARD8 mogu uticati na rizik od bolesti povezanih sa azbestom.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC7282242
DOI: 10.2478/jomb-2019-0025
objavljen u SCIndeksu: 10.01.2020.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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