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Journal of Medical Biochemistry
2020, vol. 39, br. 4, str. 428-435
Veza između preeklampsije i polimorfizama sEH promotera gena i haplotipova
Sarı İsmaila, Ökten Haticeb, Aktan Çağdaşc, Cihan Esrad
aNiğde Omer Halisdemir University, Faculty of Medicine, Department of Medical Biochemistry, Niğde, Turkey
bBeykent University, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey
cBeykent University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
dNiğde Omer Halisdemir University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Niğde, Turkey

e-adresa: smlsr@hotmail.com
Projekat:
This work was supported by the Scientific Research Project Fund of Sivas Cumhuriyet University under project number T-658.

Ključne reči: epoksi-eikosatrienske kiseline; preeklampsija; rastvoriva epoksidna hidrolaza; polimorfizam; promoter gena
Sažetak
Uvod: Epoksi-ekosatrienoične kiseline (EET) imaju antihipertenzivna, protivupalna i zaštitna svojstva organa i nivoi njihove cirkulacije povezani su sa hipertenzijom, dijabetesom, kardiovaskularnim bolestima i preeklampsijom. Rastvoriva epoksidna hidrolaza (sEH) katalizuje razgradnju EET-a na biološki manje aktivne dihidroksiekosatrienoične kiseline. Uradili smo analizu sekvenci regiona promotera EPHKS2 da bismo istražili povezanost izmena sekvenci promotera za koje smo mislili da utiču na nivoe ekspresije enzima i preeklampsije (PE). Metode: Nukleotidno sekvenciranje promoterske regije EPHKS2, koje se proteže od položaja -671 do +30 izvršeno je na 100 trudnica sa PE, kao i na ženama koje su bile trudne 20 ili više nedelja, a koje su bile zdrave i sa normalnim krvnim pritiskom (n = 100). Rezultati: Trudnice koje nose rs4149235, rs4149232, rs73227309 i rs62504268 polimorfizme imaju 4,4, 2,4, 2,3 i 2,8 puta značajno povećan rizik od PE. CCGG (OR: 3,11; 95% CI: 1,12-8,62) i CCCA (OR: 0,45; 95% CI: 0,36-0,55) haplotipovi su povezani sa povećanim i smanjenim rizikom od PE. Zaključak: četiri SNP-a (rs4149232, rs4149235, rs73227309 i rs62504268) u promoterskoj regiji EPHKS2, i CCGG i CCCA haplotipovi ova 4 SNP-a su u značajnoj vezi sa PE. Ovi SNP-ovi u promoterskoj regiji mogu uticati na ekspresiju sEH, a time i na aktivnosti enzima i mogu igrati ulogu u patogenezi PE uzrokujući pojedinačne razlike u nivoima EET-a. Međutim, potrebno je sprovesti dodatne studije u budućnosti da se potvrde naša otkrića i da se ispita uticaj ovih SNP-a na sEH ekspresiju i/ili aktivnost enzima.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC7710375
DOI: 10.5937/jomb0-27745
objavljen u SCIndeksu: 02.10.2020.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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