Metrics

  • citations in SCIndeks: 0
  • citations in CrossRef:[1]
  • citations in Google Scholar:[]
  • visits in previous 30 days:24
  • full-text downloads in 30 days:12

Contents

article: 9 from 76  
Back back to result list
2020, vol. 39, iss. 1, pp. 91-99
NLRP3 and CARD8 polymorphisms influence risk for asbestos-related diseases
aUniversity Medical Centre Ljubljana, Clinical Institute of Occupational Medicine, Ljubljana, Slovenia
bUniversity of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia
cInstitute of Oncology Ljubljana, Ljubljana, Slovenia
Project:
This work was financially supported by the Slovenian Research Agency (ARRS Grants No. P1-0170, L3-8203)

Keywords: inflammasome; polymorphism; asbestosis; pleural plaques; malignant mesothelioma
Abstract
Background: This study aimed to investigate the association between NLRP3 rs35829419 and CARD8 rs2043211 polymorphisms and the risk of developing pleural plaques, asbestosis, and malignant mesothelioma (MM), and to study the influence of the interactions between polymorphisms and asbestos exposure on the risk of developing these diseases. Methods: The case-control study included 416 subjects with pleural plaques, 160 patients with asbestosis, 154 subjects with MM and 149 subjects with no asbestos disease. The NLRP3 rs35829419 and CARD8 rs2043211 polymorphisms were determined using real-time PCR-based methods. In the statistical analysis, standard descriptive statistics was followed by univariate and multivariate logistic regression modelling. Results: Asbestos exposure (medium and high vs low) was associated with the risk for each studied asbestos-related disease. An increased risk of pleural plaques was found for CARD8 rs2043211 at + TT genotypes (OR = 1.48, 95% CI 1.01-2.16, p = 0.042). When the analysis was performed for MM patients as cases, and pleural plaques patients as controls, a decreased MM risk was observed for carriers of CARD8 rs2043211 TT genotype (OR = 0.52, 95% CI 0.27-1.00, p = 0.049). The interactions between NLRP3 rs35829419 and CARD8 rs2043211 genotypes did not influence the risk of any asbestos-related disease. However, when testing interactions with asbestos exposure, a decreased risk of asbestosis was found for NLRP3 CA+AA genotypes (OR = 0.09, 95% CI 0.01-0.60, p = 0.014). Conclusions: The results of our study suggest that NLRP3 and CARD8 polymorphisms could affect the risk of asbestos-related diseases.
References
American Thoracic Society (2004) Diagnosis and Initial Management of Nonmalignant Diseases Related to Asbestos. American Journal of Respiratory and Critical Care Medicine, 170(6): 691-715
Bhattacharjee, P., Paul, S., Bhattacharjee, P. (2016) Risk of occupational exposure to asbestos, silicon and arsenic on pulmonary disorders: Understanding the genetic-epigenetic interplay and future prospects. Environmental Research, 147: 425-434
Chapman, S.J., Cookson, W.O.C., Musk, W.A., Lee, G.Y.C. (2003) Benign asbestos pleural diseases. Current Opinion in Pulmonary Medicine, 9(4): 266-271
Chew, S.H., Toyokuni, S. (2015) Malignant mesothelioma as an oxidative stress-induced cancer: An update. Free Radical Biology and Medicine, 86: 166-178
Clarke, C.C., Mowat, F.S., Kelsh, M.A., Roberts, M.A. (2006) Pleural Plaques: A Review of Diagnostic Issues and Possible Nonasbestos Factors. Archives of Environmental & Occupational Health, 61(4): 183-192
Comar, M., Zanotta, N., Bonotti, A., Tognon, M., Negro, C., Cristaudo, A., Bovenzi, M. (2014) Increased Levels of C-C Chemokine RANTES in Asbestos Exposed Workers and in Malignant Mesothelioma Patients from an Hyperendemic Area. PLoS One, 9(8): e104848-e104848
Cugell, D.W., Kamp, D.W. (2004) Asbestos and the pleura: A review. Chest, 125(3): 1103-1117
da Silva, W.C., Oshiro, T.M., de Sá, D.C., Franco, D.D.G.S., Neto, C.F., Pontillo, A. (2016) Genotyping and differential expression analysis of inflammasome genes in sporadic malignant melanoma reveal novel contribution of CARD8, IL1B and IL18 in melanoma susceptibility and progression. Cancer Genetics, 209(10): 474-480
Dolzan, V., Dodic-Fikfak, M., Franko, A. (2017) Gene-Environment Interactions: The Case of Asbestosis. in: Korhan O. [ed.] Occupational Health, Rijeka: InTech, 159-78
Dostert, C., Petrilli, V., van Bruggen, R., Steele, C., Mossman, B.T., Tschopp, J. (2008) Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica. Science, 320(5876): 674-677
Dunn, J.H., Ellis, L.Z., Fujita, M. (2012) Inflammasomes as molecular mediators of inflammation and cancer: Potential role in melanoma. Cancer Letters, 314(1): 24-33
Ferris, B.G. (1978) Epidemiology Standardization Project. Am Rev Respir Dis, 118: 1-120
Fikfak, M.D., Kriebel, D., Quinn, M.M., Eisen, E.A., Wegman, D.H. (2007) A Case Control Study of Lung Cancer and Exposure to Chrysotile and Amphibole at a Slovenian Asbestos-Cement Plant. Annals of Occupational Hygiene, 51: 261-269
Fishwick, D., Barber, C.M. (2014) Non-malignant asbestos-related diseases: A clinical view. Clinical Medicine, 14(1): 68-71
Fontalba, A., Martinez-Taboada, V., Gutierrez, O., Pipaon, C., Benito, N., Balsa, A., Blanco, R., Fernandez-Luna, J.L. (2007) Deficiency of the NF-cB Inhibitor Caspase Activating and Recruitment Domain 8 in Patients with Rheumatoid Arthritis Is Associated with Disease Severity. Journal of Immunology, 179(7): 4867-4873
Frank, A.L., Joshi, T.K. (2014) The global spread of asbestos. Annals of global health, 80: 257-62
Franko, A., Dolžan, V., Arnerić, N., Dodič-Fikfak, M. (2013) The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis. BioMed Research International, 2013: 1-7
Franko, A., Dolzan, V., Kovac, V., Arneric, N., Dodic-Fikfak, M. (2012) Soluble Mesothelin-Related Peptides Levels in Patients with Malignant Mesothelioma. Disease Markers, 32(2): 123-131
Franko, A., Kotnik, N., Goricar, K., Kovac, V., Dodic-Fikfak, M., Dolzan, V. (2018) The influence of genetic variability on the risk of developing malignant mesothelioma. Radiology and Oncology, 52(1): 105-111
Gross, O., Thomas, C.J., Guarda, G., Tschopp, J. (2011) The inflammasome: An integrated view. Immunological Reviews, 243(1): 136-151
Hillerdal, G., Henderson, D.W. (1997) Asbestos, asbestosis, pleural plaques and lung cancer. Scandinavian Journal of Work, Environment & Health, 23(2): 93-103
Ito, S., Hara, Y., Kubota, T. (2014) CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction. Arthritis Research & Therapy, 16(1): R52-R52
Jakobsson, K., Stromberg, U., Albin, M., Welinder, H., Hagmar, L. (1995) Radiological changes in asbestos cement workers. Occupational and Environmental Medicine, 52(1): 20-27
Jamrozik, E., de Klerk, N., Musk, A.W. (2011) Asbestos-related disease. Internal Medicine Journal, 41(5): 372-380
Kaczanowski, S. (2016) Apoptosis: Its origin, history, maintenance and the medical implications for cancer and aging. Physical Biology, 13(3): 031001-031001
Kadariya, Y., Menges, C.W., Talarchek, J., Cai, K.Q., Klein-Szanto, A.J., Pietrofesa, R.A., Christofidou-Solomidou, M., Cheung, M., Mossman, B.T., Shukla, A., Testa, J.R. (2016) Inflammation-Related IL1 beta/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma. Cancer Prevention Research, 9(5): 406-414
Kamp, D.W., Weitzman, S.A. (1999) The molecular basis of asbestos induced lung injury. Thorax, 54(7): 638-652
Kovac, V., Dodic-Fikfak, M., Arneric, N., Dolzan, V., Franko, A. (2015) Fibulin-3 as a biomarker of response to treatment in malignant mesothelioma. Radiology and Oncology, 49(3): 279-285
Kukkonen, M.K., Vehmas, T., Piirilä, P., Hirvonen, A. (2014) Genes involved in innate immunity associated with asbestos-related fibrotic changes. Occupational and Environmental Medicine, 71(1): 48-54
Leek, R.D., Lewis, C.E., Whitehouse, R., Greenall, M., Clarke, J., Harris, A.L. (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research, 56: 4625-4634
Matsuzaki, H., Maeda, M., Lee, S., Nishimura, Y., Kumagai-Takei, N., Hayashi, H., Yamamoto, S., Hatayama, T., Kojima, Y., Tabata, R., Kishimoto, T., Hiratsuka, J., Otsuki, T. (2012) Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. Journal of Biomedicine and Biotechnology, 2012: 1-9
Maxim, L., Niebo, R., Utell, M.J. (2015) Are pleural plaques an appropriate endpoint for risk analyses?. Inhalation Toxicology, 27(7): 321-334
Milinković, N., Ignjatović, S., Šumarac, Z., Majkić-Singh, N. (2018) Uncertainty of measurement in laboratory medicine. Journal of Medical Biochemistry, vol. 37, br. 3, str. 279-288
Mossman, B.T., Churg, A. (1998) Mechanisms in the Pathogenesis of Asbestosis and Silicosis. American Journal of Respiratory and Critical Care Medicine, 157(5): 1666-1680
Mossman, B.T., Gee, B.J.L. (1989) Asbestos-Related Diseases. New England Journal of Medicine, 320(26): 1721-1730
Peters, G.A., Peters, B.J. (1980) Medical aspects. in: Peters GA, Peters BJ [ed.] Sourcebook on asbestos diseases: Medical, legal, and engineering aspects, New York-London: Garland STPM Press, 2-6
Pétrilli, V., Dostert, C., Muruve, D.A., Tschopp, J. (2007) The inflammasome: A danger sensing complex triggering innate immunity. Current Opinion in Immunology, 19(6): 615-622
Ribatti, D., Ennas, M.G., Vacca, A., Ferreli, F., Nico, B., Orru, S., Sirigu, P. (2003) Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. European Journal of Clinical Investigation, 33(5): 420-425
Speizer, F.E., Balmes, J.R. (2008) Environmental lung disease. in: Fauci A, Braunwald E, Kasper D, Hauser S, Longo D, Jameson J, et al. [ed.] Harrison's Principles of Internal Medicine, New York-Chicago-San Francisco-Lisbon-London-Madrid-Mexico City-New Delhi-San Juan-Seoul-Singapore-S: McGraw Hill, 17th Edition. 1612-1616
Stayner, L., Welch, L.S., Lemen, R. (2013) The Worldwide Pandemic of Asbestos-Related Diseases. Annual Review of Public Health, 34(1): 205-216
Straif, K., Benbrahim-Tallaa, L., Baan, R., Grosse, Y., Secretan, B., El, G.F., Bouvard, V., Guha, N., Freeman, C., Galichet, L., Cogliano, V. (2009) A review of human carcinogens: Part C: Metals, arsenic, dusts, and fibres. Lancet Oncology, 10(5): 453-454
Tomasetti, M., Santarelli, L. (2010) Biomarkers for Early Detection of Malignant Mesothelioma: Diagnostic and Therapeutic Application. Cancers, 2(2): 523-548
Vainio, H. (2015) Epidemics of asbestos-related diseases: Something old, something new. Scandinavian Journal of Work, Environment & Health, 41(1): 1-4
Vasseur, F., Sendid, B., Broly, F., Gower-Rousseau, C., Sarazin, A., Standaert-Vitse, A., Colombel, J., Poulain, D., Jouault, T. (2013) The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease. BMC Medical Genetics, 14(1): 35-35
Verma, D., Lerm, M., Blomgran, J.R., Eriksson, P., Söderkvist, P., Särndahl, E. (2008) Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: Relation to common inflammatory diseases?. Arthritis & Rheumatism, 58(3): 888-894
Verma, D., Särndahl, E., Andersson, H., Eriksson, P., Fredrikson, M., Jönsson, J., Lerm, M., Söderkvist, P. (2012) The Q705K Polymorphism in NLRP3 Is a Gain-of-Function Alteration Leading to Excessive Interleukin-1b and IL-18 Production. PLoS One, 7(4): e34977-e34977
Westbom, C., Thompson, J.K., Leggett, A., Macpherson, M., Beuschel, S., Pass, H., Vacek, P., Shukla, A. (2015) Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma. PLoS One, 10(12): e0145404-e0145404
Wu, Y.Z., Antony, S., Meitzler, J.L., Doroshow, J.H. (2014) Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Letters, 345(2): 164-173
Ying, S.B., Jiang, Z.Q., He, X.L., Yu, M., Chen, R.P., Chen, J.P., Ru, G., Chen, Y.P., Chen, W.P., Zhu, L., Li, T., Zhang, Y., Guo, X., Yin, X., Zhang, X., Lou, J. (2017) Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases. Disease Markers, 2017: 1-9
Zhang, Z.T., Ma, X.J., Zong, Y., Du, X.M., Hu, J.H., Lu, G.C. (2015) Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis. Autoimmunity, 48(8): 524-531
 

About

article language: English
document type: Original Scientific Paper
PMC ID: PMC7282242
DOI: 10.2478/jomb-2019-0025
published in SCIndeks: 10/01/2020
peer review method: double-blind
Creative Commons License 4.0

Related records

No related records