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2021, vol. 10, br. 1, str. 11-19
Fizička, hemijska i antioksidativna studija stabilnosti topikalne formulacije na bazi ekstrakta cveta nevena (Calendula officinalis L.)
Univerzitet u Nišu, Tehnološki fakultet, Leskovac

e-adresasavicivan@tf.ni.ac.rs
Projekat:
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (institucija: Univerzitet u Nišu, Tehnološki fakultet, Leskovac) (MPNTR - 451-03-68/2020-14/200133)

Sažetak
Ekstrakt cveta nevena (Calendula officinalis L.) ima farmakološka svojstva zbog prisustva različitih bioaktivnih jedinjenja. Poznato je da ekstrakt ima antioksidativna, antiimflamatorna, antitumorska, antibakterijska, antifugalna, antivirusna, antimutagena, antidematitisna svojstva, itd. Cilj ovog rada bio je poboljšanje kvaliteta izabrane topikalne formulacije dodatkom etanolnog ekstrakta cveta nevena, kao i praćenje njene stabilnosti. Topikalna formulacija bila je emulzija voda-u-ulju pripremljena toplo/toplo emulzifikacionim procesom sa masnom fazom koja se sastojala od vazelina, lanolina i bademovog ulja. Ekstrakt pripremljen ultrazvučnom ekstrakcijom imao je sadržaj antioksidanasa 3,512 g ekvivalenta galne kiseline 100 g-1 suve mase i polovinu maksimalne inhibitorne koncentracije 0.14 mg mL-1 određena DPPH testom. Studija hemijske stabilnosti pokazala je da dnevna svetlost nema značajan uticaj na stabilnost antioksidanasa u ekstraktu, dok povećanje temperature dovodi do njihove degradacije. Rok trajanja ekstrakta je oko 8 meseci na 4 °C i 3 meseca na 22 °C (sobna temperatura). Pripremljene nekategorisane topikalne formulacije koje sadrže 1% i 2% (m/m) ekstrakta cveta nevena bile su stabilne na različitim temperaturama tokom čuvanja. Nekategorisane formulacije su pokazivale antioksidativnu aktivnost, ali se aktivnost ekstrakta u formulacijama smanjivala sa povećanjem temperature čuvanja. Ekstrakt cveta nevena i razvijene nekategorisane formulacije su pokazale inhibitornu aktivnost na Gram-pozitivnim (Staphylococcus aureus) i Gramnegativnim bakterijama (Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae), kao i na Candida albicans. Nekategorisane formulacije sa ovom aktivnošću se mogu koristiti kod tretmana kožnih infekcija.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.5937/savteh2101011S
primljen: 20.03.2020.
prihvaćen: 27.04.2021.
objavljen u SCIndeksu: 10.07.2021.