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2019, vol. 69, iss. 3, pp. 199-212
Cosmetic products and non-invasive aesthetic procedures: Safety of usage and recommendations regarding selection during pregnancy and lactation
aVisoka zdravstvena škola strukovnih studija u Beogradu, Beograd
bUniversity of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology
Keywords: cosmetic products; non-invasive aesthetic procedures; safety; pregnancy; lactation; recommendations
Changes of the skin and skin appendages, which occur during pregnancy, are often the cause of discontentment and the reason why pregnant and breastfeeding women use numerous cosmetic products on the daily basis and show the interest for the different aesthetic procedures. Although safety of cosmetic products must be confirmed before the product is placed on the market, the fact is that their safety, as well as the safety of aesthetic procedures, is not estimated on pregnant or breastfeeding women. The selection of an appropriate product is further complicated by the absence of the list of allowed raw materials which should be considered during pregnancy and lactation, especially for substances that are known or potential endocrine disruptors or substances which are (potentially) toxic for the reproduction. Additionally, there are no official recommendations issued by the regulatory bodies or any healthcare associations, which would facilitate the selection of cosmetic products during pregnancy and breastfeeding and reduce the possible fear regarding the exposure of fetus/baby to unsafe ingredients. The paper provides an overview of the safety data of the specified cosmetic ingredients, different categories of cosmetic products and non-invasive aesthetic procedures, with an attempt to consolidate those data into the specific recommendations regarding selection and their usage during pregnancy and lactation.
*** (2018) Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 Nov 2009 on cosmetic products. (consolidated version of 01/08) [cited 2019 June 25]. Available from:
*** (2019) Zakon o predmetima opšte upotrebe. Službeni glasnik RS, 25
Andersen, A.F. (2011) Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010. International Journal of Toxicology, 30(5_suppl): 73S-127S
Arora, H., Tosti, A. (2017) Safety and Efficacy of Nail Products. Cosmetics, 4(3): 24-24
Babilas, P., Schreml, S., Szeimies, R.M., Landthaler, M. (2010) Intense pulsed light (IPL): A review. Lasers in Surgery and Medicine, 42(2): 93-104
Bavoux, C., Picot, V., Roudot, A., Verdier, C., Sater, N., Ould, E.M., Desmares, C. (2011) Pregnant women exposure assessment to cosmetic products. Toxicology Letters, 205(205): S255-S256
Bernard, A., Dornic, N., Roudot, A., Ficheux, A. (2018) Probabilistic exposure assessment to face and oral care cosmetic products by the French population. Food and Chemical Toxicology, 111: 511-524
Biesterbos, J.W.H., Dudzina, T., Delmaar, C.J.E., Bakker, M.I., Russel, F.G.M., von Goetz, N., Scheepers, P.T.J., Roeleveld, N. (2013) Usage patterns of personal care products: Important factors for exposure assessment. Food and Chemical Toxicology, 55: 8-17
Braun, J.M., Just, A.C., Williams, P.L., Smith, K.W., Calafat, A.M., Hauser, R. (2014) Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. Journal of Exposure Science & Environmental Epidemiology, 24(5): 459-466
Chien, A.L., Qi, J., Rainer, B., Sachs, D.L., Helfrich, Y.R. (2016) Treatment of Acne in Pregnancy. Journal of the American Board of Family Medicine, 29(2): 254-262
Chongo-Faruk, V. (2016) Allergies and other occupational diseases in the hairdressing industry: Allergies in the workplace. Curr Allergy Clin Im, 29(3): 180-88
Chua-Gocheco, A., Bozzo, P., Einarson, A. (2008) Safety of hair products during pregnancy: Personal use and occupational exposure. Can Fam Physician, 54(10): 1386-1394
Cosmetic Ingredient Review Expert Panel (2005) Annual Review of Cosmetic Ingredient Safety Assessments: 2002/2003. International Journal of Toxicology, 24(1_suppl): 1-102
de Renzy-Martin, K.T., Frederiksen, H., Christensen, J.S., Kyhl, H.B., Andersson, A.M., Husby, S., Barington, T., Main, K.M., Jensen, T.K. (2014) Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols. Reproduction, 147(4): 443-453
Draelos, Z.D. (2013) Cosmetic treatment of nails. Clinics in Dermatology, 31(5): 573-577
Đukić-Ćosić, D., Antonijević, B. (2018) Zašto je potrebna toksikološka procena rizika za kozmetički proizvod?. Arhiv za farmaciju, vol. 68, br. 5, str. 971-989
Etzel, T.M., Calafat, A.M., Ye, X., Chen, A., Lanphear, B.P., Savitz, D.A., Yolton, K., Braun, J.M. (2017) Urinary triclosan concentrations during pregnancy and birth outcomes. Environmental Research, 156: 505-511
Ficheux, A.S., Wesolek, N., Chevillotte, G., Roudot, A.C. (2015) Consumption of cosmetic products by the French population: First part: Frequency data. Food and Chemical Toxicology, 78: 159-169
Ghazarian, A.A., Trabert, B., Robien, K., Graubard, B.I., McGlynn, K.A. (2018) Maternal use of personal care products during pregnancy and risk of testicular germ cell tumors in sons. Environmental Research, 164: 109-113
Gontijo, G., Gualberto, G.V., Madureira, N.A. (2010) Dermatologic surgery and cosmetic procedures during pregnancy: A systematic review. Surg Cosmet Dermatol, 2(1): 39-45
Kar, S., Krishnan, A., Shivkumar, P.V. (2012) Pregnancy and Skin. Journal of Obstetrics and Gynecology of India, 62(3): 268-275
Kaushik, S.B., Alexis, A.F. (2017) Nonablative fractional laser resurfacing in skin of color: Evidence-based review. J Clin Aesthet Dermatol, 10(6): 51-67
Kim, D., Kang, M.Y., Choi, S., Park, J., Lee, H.J., Kim, N. (2016) Reproductive disorders among cosmetologists and hairdressers: A meta-analysis. International Archives of Occupational and Environmental Health, 89(5): 739-753
Konda, D., Thappa, D. (2013) Mesotherapy: What is new?. Indian J Dermatol Venereol Leprol, 79(1): 127-161
Lee, K.C., Korgavkar, K., Dufresne, R.G., Higgins, W.H. (2013) Safety of Cosmetic Dermatologic Procedures During Pregnancy. Dermatologic Surgery, 39(11): 1573-1586
Lukić, M. (2018) Konzervansi, sredstva za bojenje i UV filteri u kozmetičkim proizvodima - aspekti bezbedne primene. Arhiv za farmaciju, vol. 68, br. 5, str. 934-948
Maluf, D.F., Roters, F., Silva, L.C.F. (2017) Current Cosmetic Treatments in Pregnancy. Int J Med Health Sci, 11(3): 100-106
Marie, C., Cabut, S., Vendittelli, F., Sauvant-Rochat, M.P. (2016) Changes in Cosmetics Use during Pregnancy and Risk Perception by Women. International Journal of Environmental Research and Public Health, 13(4): 383-383
Nohynek, G.J. (2017) Commentary on the safety of topical vitamin A in cosmetics. Regulatory Toxicology and Pharmacology, 89: 302-304
Nohynek, G.J., Antignac, E., Re, T., Toutain, H. (2010) Safety assessment of personal care products/cosmetics and their ingredients. Toxicology and Applied Pharmacology, 243(2): 239-259
Nohynek, G.J., Skare, J.A., Meuling, W.J.A., Wehmeyer, K.R., de Bie, A.Th.H.J., Vaes, W.H.J., Dufour, E.K., Fautz, R., Steiling, W., Bramante, M., Toutain, H. (2015) Human systemic exposure to [ 14 C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment. Food and Chemical Toxicology, 81: 71-80
Paasch, U., Bodendorf, M.O., Grunewald, S., Simon, J.C. (2009) Skin rejuvenation by radiofrequency therapy: Methods, effects and risks. Journal der Deutschen Dermatologischen Gesellschaft, 7(3): 196-203
Pak, V.M., Powers, M., Liu, J. (2013) Occupational Chemical Exposures Among Cosmetologists: Risk of Reproductive Disorders. Workplace Health & Safety, 61(12): 522-528
Pugashetti, R., Shinkai, K. (2013) Treatment of acne vulgaris in pregnant patients. Dermatologic Therapy, 26(4): 302-311
Savić, S., Paunović, J. (2018) Bezbednost kozmetičkih proizvoda u svetlu evropskih propisa - kozmetička uredba 1223/2009. Arhiv za farmaciju, vol. 68, br. 5, str. 911-933
Scientific Committee on Consumer Safety (SCCS) (2014) Memorandum on Endocrine Disruptors. SCCS/1544/14, 16 December [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2012) Opinion on p-phenylenediamine. 26-27 June [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2016) Opinion on Vitamin A (Retinol, Retinyl Acetate, Retinyl Palmitate). SCCS/1576/16, 20 April, final version of 6 October 2016, CORRIGENDUM on 23 December 2016 [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2014) Opinion on the safety of the use of formaldehyde in nail hardeners. SCCS/1538/14, written procedure 7 November, revision of 16 December 2014 [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2017) Opinion on the safety of cosmetic ingredients HEMA (CAS 868-77-9) and Di-HEMA Trimethylhexyl Dicarbamate (CAS 41137-60-4/72869-86-4)-Submission I (Sensitisation only). SCCS/1592/17, preliminary version adopted on 22 December, final version adopted on 21-22 June 2018 [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2018) SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation. 10th revision, 24-25 October, SCCS/1602/18 [cited 2019 June 25]. Available from: 24.pdf
Scientific Committee on Consumer Safety (2018) Opinion on salicylic acid (CAS 69-72-7): Submission I. preliminary version of 10 September, final version of 21 December 2018, SCCS/1601/18 [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2010) Opinion on dihydroxyacetone. 14 December [cited 2019 June 25]. Available from:
Scientific Committee on Consumer Safety (SCCS) (2008) Opinion on toluene. 15 April [cited 2019 June 25]. Available from:
Steinberg, B.J., Hilton, I.V., Iida, H., Samelson, R. (2013) Oral Health and Dental Care During Pregnancy. Dental Clinics of North America, 57(2): 195-210
Sur, D., Chakravorty, R. (2015) The Effects of Topically-Applied Skin Moisturizer on Striae Gravidarum in East Indian Women. Journal of Clinical & Experimental Dermatology Research, 06(06): 303-303
Toivo, T., Orreveteläinen, P., Kännälä, S., Toivonen, T. (2017) Survey on limiting exposure to ultrasound. Helsinki, STUK-TR 26. 25 pp + appendix 5 p. ISBN 978-952-309-381-2 [cited 2019 June 25]. Available from:
Trivedi, M.K., Kroumpouzos, G., Murase, J.E. (2017) A review of the safety of cosmetic procedures during pregnancy and lactation. International Journal of Women's Dermatology, 3(1): 6-10
Tyler, K.H. (2015) Physiological Skin Changes During Pregnancy. Clinical Obstetrics and Gynecology, 58(1): 119-124


article language: Serbian
document type: Professional Paper
DOI: 10.5937/arhfarm1903199F
published in SCIndeks: 09/11/2019
Creative Commons License 4.0

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