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2023, vol. 51, br. 4, str. 594-612
Mefentriflukonazol - novi fungicid iz grupe triazola
Univerzitet u Beogradu, Poljoprivredni fakultet, Srbija

e-adresanadjaamilutinovic10@gmail.com
Ključne reči: mefentriflukonazol; triazoli; strna žita; testovi toksičnosti; rizik
Sažetak
Mefentriflukonazol je nova aktivna supstanca sa fungicidnim delovanjem, koja pripada izopropanol azolima, novoj podgrupi u okviru hemijske grupe triazola. Inhibira biosintezu sterola i odlikuje se veoma selektivnim delovanjem. Sistemični je fungicid sa protektivnim, kurativnim i eradikativnim delovanjem i koristi se za suzbijanje značajnih patogena strnih žita (Septoria spp., Puccinia spp., Ramularia collo-cygni, Rhynchosporium secalis). Za razliku od većine triazola, povučenih iz primene u poslednje 2-3 godine, uglavnom zbog repro-toksičnog i karcinogenog delovanja, mefentriflukonazol ne deluje karcinogeno, genotoksično ni reprotoksično. Takođe, nije akutno toksičan, ne iritira kožu i oči i ne izaziva specifičnu toksičnost za ciljne organe posle jednokratne ili višekratne izloženosti. U dodiru sa kožom može izazvati senzibilizaciju i to je jedino toksikološko svojstvo na osnovu koga je klasifikovan i obeležen. Akutna i hronična dijetarna izloženost svih populacionih grupa ovoj aktivnoj supstanci je niska, sa velikom marginom bezbednosti. Mefentriflukonazol nije akutno oralno i kontakt-no toksičan za pčele i nije toksičan za kišne gliste. Za akvatične organizme, ribe, beskičmenjake i alge je veoma toksičan akutno i hronično, dok je za organizme sedimenta i akvatične makrofite toksičan. Povoljna toksikološka svojstva mefen-triflukonazola i dobra efikasnost preporučuju ovu aktivnu supstancu kao dobru zamenu za triazole povučene iz primene.
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O članku

jezik rada: srpski
vrsta rada: neklasifikovan
DOI: 10.5937/BiljLek2304594M
objavljen u SCIndeksu: 28.07.2023.

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