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Serbian Journal of Experimental and Clinical Research
2019, vol. 20, iss. 3, pp. 207-214
article language: English
document type: Original Scientific Paper
published on: 06/02/2020
doi: 10.2478/SJECR-2018-0057
Assessment of the TDCS influence on stress-induced disorders in rats with low stress sustainability and endurance
aKuban State Medical University, Russia, Department of Common and Clinical Pathophysiology, Krasnodar, Russia
bRostov State Medical University, Russia, Department of Pathophysiology, Rostov-on-Don, Russia

e-mail: a-lipatova@yandex.ru

Abstract

The aim of study is to analyze the tDCS infl uence on stressinduced disorders in rats with low stress sustainability and endurance. e animals with a low stress sustainability and endurance were divided into 3 groups: the comparison 1, the comparison 2 and the main. e control group consisted of intact rats. e rats of the comparison group 1 were subjected to orthostatic stress 24 hours after the 1st forced swimming test. e rats of the comparison group 2 and the main one were conducted the 2nd forced swimming test on the 7th day of the experiment, and 24 hours later they were subjected to the orthostatic stress. Rats of the main group got tDCS sessions after the 1st forced swimming test. e development of the orthostatic stress is accompanied by an increase in plasma content the following components: adrenaline by 88.9%, ACTH in 10.5 times, corticosterone by 70.1%, IL-1β by 178.2%, IL-6 in 6.7 times, IL-10 by 37.1% in comparison with intact animals. e usage of tDCS in rats with low stress sustainability and endurance increased the swimming duration by 47.7%. During the OS it was also accompanied by a decrease in plasma content: adrenaline in 1.4 times, ACTH in 8.2 times, corticosterone in 1.4 times, IL-1β in 1.5 times, IL-6 in 2.2 times, IL-10 in 1.2 times, relative to the comparison group 2. e obtained data showed the essential eff ect of tDCS on stress-related changes in the content of cytokines and hormones of blood.

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