In current modern age of worldwide processes of globalization and globalism a process of desovereigntization of national state and economy has become a general process. Therefore national state has been faced with numerous challenges and it has been in a permanent state of crisis. Within the process of globalization most often rich enclaves of national states make attempts to integrate themselves into neoliberal capitalist system, while poor and backward enclaves become abandoned and so national states become disintegrated. First of all it is necessary to search for causes of ethno-religious conflicts and a national separatism in the field of economy. Within the globalization environment it happened that old entities, national state, national economy and national security gained totally new meanings. By using a method of comparative analysis of document contents and consitutional and political practice alike it is possible to reach conclusion that a great number of modern national states, including the Republic of Serbia among them, have found themselves in the state of permanent crisis, and the state crisis implies, before anything else, the crisis of state sovereignty. The state gets destroyed both from inside and outside in different ways. By using a quality method it is confirmed that within a state there comes an overstepping of constitutional regulations which encompass, before else, the issues of national economy and national security, and it is achieved in particular by seizure of economic sovereignty.