This paper aims to examine Serbian female entrepreneurs' performance related to digital competences based on real-life scenario questions. The research was conducted on a sample of 114 female entrepreneurs. The method used for collecting data was an online survey (Google form). The survey questions were based on Digital Competence Framework (DigComp) focusing on the first two areas, "Information and data literacy" and "Communication and collaboration". The results showed that the female entrepreneurs in Serbia achieved better performance (i.e., answered the questions correctly) in the area "Information and data literacy" especially in the segment "Browsing, searching, and filtering data, information and digital content". On the other side, lower performance of Serbian female entrepreneurs was achieved in the area "Communication and collaboration", where nine questions from thirteen were not answered correctly. Segments "Engaging in citizenship through digital technologies", "Collaborating through digital technologies" and "Netiquette" were identified as the most problematic because there was no correct answer. The authors can conclude that skills incorporated in the segments of the second area need to be improved and boosted to be in line with market demands.