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Analiza potrošnje antibiotika i bakterijske rezistencije u tercijernom Zdravstvenom centru Niš
aKlinički centar Niš + Univerzitet u Nišu, Medicinski fakultet
bUniverzitet u Nišu, Medicinski fakultet
cKlinički centar Niš
dUniverzitet u Nišu, Medicinski fakultet + Public Health Institute of Nis, Nis
ePublic Health Institute of Nis, Nis

e-adresafarmakoterapija@yahoo.com
Projekat:
Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (MPNTR - 41018)

Sažetak
Uvod: Antibiotici su među najčešće korišćenim lekovima kod hospitalizovanih pacijenata. Istraživanja su pokazala da se antibiotici često neracionalno primenjuju što značajno doprinosi razvoju bakterijske otpornosti. Cilj ovog rada je evaluacija potrošnje antibiotika u Kliničkom centru Niš, sa akcentom na monitoring potrošnje ceftriaksona (CTX) i ciprofloxacina (CIP). Uporedo sa potrošnjom antibiotika prikazana je bakterijska otpornost prema antibioticima koji se koristi za terapiju intraabdominalnih (IAI) i urinarnih infekcija (UTI). Metode: Potrošnja antibiotika i antimikrobna otpornost praćene su u tercijarnoj zdravstvenoj ustanovi - Kliničkom centru Niš od 2011. do 2014. Korišćenjem Anatomical Therapeutic Chemical/Defined Daily Dose metodologije ukupna potrošnja antibiotika izražavana je brojem definisanih dnevnih doza na 100 bolesničkih dana (DBD). Ispitivanje i praćenje osetljivosti bakterija vršeno je u Institutu za zaštitu zdravlja u Nišu. Bakterijska rezistencija izražavana je procentom rezistentnih sojeva bakterija. Rezultati: U toku ispitivanog perioda upotreba cefalosporina je povećana za 6,39%, od 2011. do 2013. godine, dok je 2014. godine utvrđeno smanjenje potrošnje za 16.46%. Potrošnja penicilina je smanjena, dok je potrošnja hinolona bila promenljivu toku perioda praćenja. Registrovan je rastući trend otpornosti K. pneumoniae prema CTX i CIP u lečenju IAI i E. coli u terapiji UTI u navedenom periodu. Zaključci: Naši rezultati pokazuju da su cefalosporini najčešće korišćeni antibiotici u Kliničkom centru Niš, nakon čega slede penicilini i hinoloni. Povećana je otpornost K. pneumoniae prema CTX i CIP u lečenju IAI i E. coli prema CTX i CIP u terapiji UTI, tokom ispitivanog perioda.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.5937/hpimj1601341V
objavljen u SCIndeksu: 09.09.2016.
Creative Commons License 4.0

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