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2001, vol. 58, br. 3, str. 323-328
Mikroskopski poliangiitis
aVojnomedicinska akademija, Klinika za nefrologiju, Beograd
bVojnomedicinska akademija, Beograd
cVojnomedicinska akademija, Institut za patologiju i sudsku medicinu, Beograd
dVojnomedicinska akademija, Klinika za pulmologiju, Beograd
Sažetak
Mikroskopski poliangiitis je retko oboljenje koje karakterišu lezije arteriola, venula i kapilara pre svega bubrega i pluća, ali i drugih sistema i organa. Veoma važna imunološka osobenost je i povećan titar antimijeloperoksidaznih ANCA. Kod našeg bolesnika u kliničkoj slici dominirale su promene na plućima (hemoptizije) i bubrezima (rapidno progresivni glomerulonefritis). Započeto lečenje po standardnoj Fauci-jevoj shemi koja je prilagođena prema težini bolesti i godinama bolesnika (prednizon 60 mg/24 h uz postepeno smanjenje doze, ciklofosfamid 150 mg/24 h) dovelo je do kliničko-laboratorijske remisije. Bolesnik je na imunosupresivnoj terapiji neredovno kontrolisao vrednosti leukocita, zbog čega nije blagovremeno zapažena agranulocitoza. Izostanak korekcije imunosupresivne terapije i lečenja nastale pneumoiije doveo je do letalnog ishoda.
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jezik rada: srpski
vrsta rada: neklasifikovan
objavljen u SCIndeksu: 19.08.2019.

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