Introduction: It is known that music can reduce the sense of fatigue and pain during physical exercise as well as to affect the motivation. Physiological effects of music during submaximal intensity cardiopulmonary exercise tests can be examined using a treadmill. Aim: In this study we examined the impact of asynchronous music on cardiopulmonary parameters of students, while they were running on the treadmill on the moderate to high load. Also we examined the difference between these two conditions. Materials and methods: This study involved 6 students from the Faculty of Medicine in Belgrade, which were tested in the conditions with and without music. In order to determine maximal oxygen consumption, maximal exercise tests were conducted in advance. During the testing phase, cardiopulmonary parameters were measured in two different conditions: on 70% of maximal measured VO2 values and on 90% of previously measured maximal VO2 values respectively. Results: The breathing frequency, ventilation, exhaled CO2 volume, blood pressure were significantly increased (p<0.05) in terms of music on a moderate rate of 70% VO2 max. On high rate of 90% VO2 max, there has been no significant changes to the parameters (p>0.05) except a decrease in blood pressure and minimal increase in VO2/kg. Conclusion: This study confirmed the influence of music on cardiopulmonary parameters and demonstrated that it can affect respiratory variables only on moderate loads. Results showed that music does not affect respiratory variables on high loads, but there was a significant decrease in blood pressure in both, moderate and high loads.