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2021, vol. 78, br. 1, str. 35-39
Mogući uticaj sniženih nivoa folne kiseline i vitamina B12 na reaktivaciju herpes simpleks virusnog keratitisa
aKlinički centar Srbije, Klinika za očne bolesti, Beograd
bKlinički centar Srbije, Klinika za očne bolesti, Beograd + Univerzitet u Beogradu, Medicinski fakultet
cCollege for Specialized Studies, Belgrade
dNaučni institut za veterinarstvo Srbije, Beograd
eUniverzitet u Beogradu, Medicinski fakultet, GAK 'Narodni front'

e-adresasb.bora@gmail.com
Ključne reči: herpesvirus 1, humani; folna kiselina; keratitis; recidiv; faktori rizika; vitamin b12
Sažetak
Uvod/Cilj. Herpetični keratitis u većini slučajeva je rekurentna bolest, a nastaje kao rezultat reaktivacije herpes simpleks virusa tipa 1 iz latentnosti u najbližoj senzornoj gangliji. Zbog toga je razumevanje mehanizma latentnosti i reaktivacije latentnog virusa važna karika u razumevanju nastanka recidivne bolesti oka. Sve više studija potvrđuje epigenetsku regulaciju reaktivacije virusa kao posledicu prisustva transkripciono aktivnog transkripta vezanog za latenciju (LAT) regiona u latentnom virusnom genomu. Aktivnost LAT regiona usmerena je na hromatinsko uređenje. Epigenetska modulacija metilacije DNA je povezana sa unosom folata i vitamina B12 ili njihovim koncentracijama u serumu. Prema našim saznanjima, ne postoji izveštaj o potencijalnoj ulozi vitamina B12 i folne kiseline u reaktivaciji HSV keratitisa. Cilj rada bio je analiza moguće uloge folne kiseline i vitamina B12 u kontroli reaktivacije okularnog herpetičnog keratitisa. Metode. Studijom je bilo obuhvaćeno 50 bolesnika starijih od 18 godina sa različitim formama herpetičnog keratitisa, kao posledicom reaktivacije herpes simpleks virusa tipa 1. Nivoi vitamina B12 i folne kiseline mereni su u akutnoj fazi bolesti. Svi bolesnici su praćeni najmanje godinu dana, a beležen je broj recidiva virusne infekcije. Rezultati. Stopa recidiva herpetičnog keratitisa bila je statistički značajno niža kod bolesnika sa višim nivoom vitamina B12 u krvi. Pored toga, stopa recidiva herpetičnog keratitisa je bila niža i kod bolesnika sa višim nivoom folne kiseline u krvi, ali sa nižom statističkom značajnošću u poređenju sa onom za vitamin B12. Zaključak. Sniženi nivoi vitamina B12 i folne kiseline mogu imati važnu ulogu u reaktivaciji herpetičnog keratitisa.
Reference
Anderson, O.S., Sant, K.E., Dolinoy, D.C. (2012) Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. Journal of Nutritional Biochemistry, 23(8): 853-859
Bertke, A.S., Swanson, S.M., Chen, J., Imai, Y., Kinchington, P.R., Margolis, T.P. (2011) A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro. Journal of Virology, 85(13): 6669-6677
Bloom, D.C., Giordani, N.V., Kwiatkowski, D.L. (2010) Epigenetic regulation of latent HSV-1 gene expression. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1799(3-4): 246-256
Blyth, W.A., Hill, T.J., Field, H.J., Harbour, D.A. (1976) Reactivation of herpes simplex virus infection by ultraviolet light and possible involvement of prostaglandins. Journal of General Virology, 33(3): 547-550
Bonneau, R.H., Sheridan, J.F., Feng, N., Glaser, R. (1993) Stress-induced modulation of the primary cellular immune response to herpes simplex virus infection is mediated by both adrenal-dependent and independent mechanisms. Journal of Neuroimmunology, 42(2): 167-176
Cliffe, A.R., Garber, D.A., Knipe, D.M. (2009) Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters. J Virol, 83(16): 8182-90
Darougar, S., Wishart, M.S., Viswalingam, N.D. (1985) Epidemiological and clinical features of primary herpes simplex virus ocular infection. British Journal of Ophthalmology, 69(1): 2-6
Gebhardt, B.M., Hill, J.M. (1988) T lymphocytes in the trigeminal ganglia of rabbits during corneal HSV infection. Invest Ophthalmol Vis Sci, 29(11): 1683-691
Jones, B.R. (1958) The clinical features of viral keratitis and a concept of their pathogenesis. Proceedings of the Royal Society of Medicine, 51(11): 917-924
Labetoulle, M., Auquier, P., Conrad, H., Crochard, A., Daniloski, M., Bouee, S., Elhasnaoui, A., Colin, J. (2005) Incidence of herpes simplex virus keratitis in France. Ophthalmology, 112(5): 888-895.e1
Liu, T., Tang, Q., Hendricks, R.L. (1996) Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. Journal of virology, 70(1): 264-271
Lopes, R.D.V.C., Teixeira, J.A., Marchioni, D., Villa, L.L., Giuliano, A.R., Luiza, B.M., Fisberg, R.M. (2017) Dietary intake of selected nutrients and persistence of HPV infection in men. International Journal of Cancer, 141(4): 757-765
Maclatchy, R.S. (1956) Herpes ophthalmicus. British Journal of Ophthalmology, 40(12): 762-764
Piyathilake, C.J., Macaluso, M., Chambers, M.M., Badiga, S., Siddiqui, N.R., Bell, W.C., Edberg, J.C., Partridge, E.E., Alvarez, R.D., Johanning, G.L. (2014) Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN. Cancer Prevention Research, Phila, 7(11): 1128-1137
Rabenau, H.F., Buxbaum, S., Preiser, W., Weber, B., Doerr, H.W. (2002) Seroprevalence of herpes simplex virus types 1 and type 2 in the Frankfurt am Main area, Germany. Medical Microbiology and Immunology, 190(4): 153-160
Rossler, H. (1956) Zur Behandlung des Herpes zoster ophthalmicus. Klin Mbl Augenheilk, 128: 727. (German)
Sainz, B., Loutsch, J.M., Marquart, M.E., Hill, J.M. (2001) Stress-associated immunomodulation and herpes simplex virus infections. Medical Hypotheses, 56(3): 348-356
Shimeld, C., Hill, T.J., Blyth, W.A., Easty, D.L. (1990) Passive immunization protects the mouse eye from damage after herpes simplex virus infection by limiting spread of virus in the nervous system. Journal of General Virology, 71(Pt 3): 681-7
Shimeld, C., Hill, T.J., Blyth, W.A., Easty, D.L. (1990) Reactivation of latent infection and induction of recurrent herpetic eye disease in mice. Journal of General Virology, 71(Pt 2): 397-404
Ślebioda, Z., Krawiecka, E., Szponar, E., Dorocka-Bobkowska, B. (2018) Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS). Journal of Oral Pathology & Medicine, 47(5): 531-537
Umbach, J.L., Kramer, M.F., Jurak, I., Karnowski, H.W., Coen, D.M., Cullen, B.R. (2008) MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature, 454(7205): 780-783
Vicetti, M.R.D., Sheridan, B.S., Harvey, S.A.K., Schreiner, R.S., Hendricks, R.L., Cherpes, T.L. (2010) 17-beta estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent. Journal of Virology, 84(1): 565-572
Xu, F., Sternberg, M.R., Kottiri, B.J., Mcquillan, G.M., Lee, F.K., Nahmias, A.J., Berman, S.M., Markowitz, L.E. (2006) Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA, 296(8): 964-73
Yang, L., Voytek, C.C., Margolis, T.P. (2000) Immunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1. Journal of Virology, 74(1): 209-217
Young, R.C., Hodge, D.O., Liesegang, T.J., Baratz, K.H. (2010) Incidence, recurrence, and outcomes of herpes simplex virus eye disease in Olmsted County, Minnesota, 1976-2007: The effect of oral antiviral prophylaxis. Archives of Ophthalmology, 128(9): 1178-83
 

O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP181001037S
primljen: 01.10.2018.
revidiran: 05.03.2019.
prihvaćen: 11.03.2019.
objavljen onlajn: 15.03.2019.
objavljen u SCIndeksu: 05.02.2021.
metod recenzije: dvostruko anoniman
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