Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:[1]
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:7
  • preuzimanja u poslednjih 30 dana:4

Sadržaj

članak: 3 od 7  
Back povratak na rezultate
2015, vol. 34, br. 4, str. 467-472
Neizvesna pouzdanost homocisteina kao metaboličkog markera za nedostatak folata i vitamina B12 kod pacijenata sa hroničnom opstruktivnom bolešću pluća
aKlinički centar Srbije, Centar za medicinsku biohemiju, Beograd
bKlinički centar Srbije, Centar za medicinsku biohemiju, Beograd + Univerzitet u Beogradu, Farmaceutski fakultet
cUniverzitet u Beogradu, Medicinski fakultet + Klinički centar Srbije, Klinika za pulmologiju, Beograd
dUniverzitet u Beogradu, Institut za molekularnu genetiku i genetičko inženjerstvo
eSociety of Medical Biochemists of Serbia, Belgrade

e-adresaandjelo.beletic@yahoo.com
Projekat:
Biomarkeri oštećenja i disfunkcije organa (MPNTR - 175036)

Ključne reči: homocistein; folat; vitamin B12; HOBP
Sažetak
Uvod: Povišena koncentracija homocisteina (Hey) može predstavljati metabolički marker nedostatka folata i vitamina B12, značajnih problema javnog zdravlja. Bolesnici sa hroničnom opstruktivnom bolešću pluća (HOBP) skloni su nedostatku ovih vitamina usled različitih razloga. Prikazana studija procenjuje pouzdanost koncentracije Hcy kao prediktora nedostatka folata i vitamina B12 kod ovih bolesnika. Metode: Studija je sprovedena u grupi od 50 osoba obolelih od HOBP (28 muškaraca/22 žene, starosti (x±SD = 49,0±14,5) godina. Koncentracije Hcy, folata i vitamina B12 su određivane hemiluminiscentnim imunoodređivanjem na mikročesticama. Statistička analiza je uključila testove Kolmogorov-Smirnov, Mann-Whitney U and x2, Spearman-ovu korelaciju i ROC analizu, uz nivo značajnosti od 0,05. Rezultati: Prosečne (SD) koncentracije folata i vitamina B-12 su iznosile 4,15 (2,16) pg/L i 465,6 (271,0) ng/L, pri čemu je samo kod vitamina B12 uočena korelacija sa nivoom Hcy (R =-0,510 (P=0,029)). Koncentracije vitamina se nisu razlikovale između polova, a starost je bila u korelaciji samo sa nivoom folata (R= 0,279 (P=0,047)). Incidenca nedostatka vitamina značajno se razlikovala (P=0,000 i P<0,000 za folat odn. vitamin B12) u zavisnosti od cut-off vrednosti u odnosu na koju je definisana (4,4; 6,6 i 8,0 pg/L - folat; 203 i 473 ng/L - vitamin B-12)-ROC analizom nije bilo moguće dokazati značaj hiperhomocisteinemije kao prediktora deficijencije. Zaključak: Pouzdanost koncentracije Hey kao markera nedostatka folata ili vitamina B12 kod bolesnika sa HOBP nije zadovoljavajuća, pa se deficijencija ovih vitamina ne može predvideti na osnovu pojave hiperhomocisteinemije.
Reference
*** (2008) Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food and Nutrition Bulletin, 29: Suppl 2: 238-44
Andersson, I., Grönberg, A., Slinde, F., Bosaeus, I., Larsson, S. (2007) Vitamin and mineral status in elderly patients with chronic obstructive pulmonary disease. Clinical Respiratory Journal, 1(1): 23-29
Burtsi, C.A., Ashwood, E.R., Bruns, D.E., eds. (2006) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. St. Louis, MO: Elsevier Saunders, 4th ed. pp. 1100-5
de Bruyn, E., Gulbis, B., Cotton, F. (2014) Serum and red blood cell folate testing for folate deficiency: New features?. European Journal of Haematology, 92(4): 354-359
Dhonukshe-Rutten, R.A., de Vries, J.H., de Bree, A., van der Put, N., van Staveren, W.A., de Groot, L.C. (2009) Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations. European Journal of Clinical Nutrition, 63: 18-30
Fimognari, F.L., Loffredo, L., di Simone, S., Sampietro, F., Pastorelli, R., Monaldo, M., Violi, F., D'angelo, A. (2009) Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease. Nutrition, Metabolism and Cardiovascular Diseases, 19(9): 654-659
GOLD. Global Strategy for Diagnosis, Management, and Prevention of COPD. Report 2015_pdf. Available at: http: Global Strategy for Diagnosis, Management, and Prevention of COPD: Report 2015. Available at: http://www.goldcopd.org. Accessed: January 9th, 2014
Green, R. (2011) Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. American Journal of Clinical Nutrition, 94(2): 666S-672S
Guéant, J.L., Alpers, D.H. (2013) Vitamin B12, a fascinating micronutrient, which influences human health in the very early and later stages of life. Biochimie, 95: 967-9
Hirayama, E., Lee, A.H., Terasawa, K., Kagawa, Y. (2010) Folate intake associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease. Asia Pacific Journal of Clinical Nutrition, 19: 103-112
Hoffman, M. (2011) Hypothesis: Hyperhomocysteinemia is an indicator of oxidant stress. Medical Hypotheses, 77(6): 1088-1093
Jiang, B., Ding, C., Yao, G., Yao, C., Zhang, Y., Ge, J., Qiu, E. (2014) Intervention effect of folic acid and vitamin B12 on vascular cognitive impairment complicated with hyperhomocysteinemia. Journal of Medical Biochemistry, vol. 33, br. 2, str. 169-174
McNulty, H., Scott, J.M. (2008) Intake and status of folate and related B-vitamins: Considerations and challenges in achieving optimal status. British Journal of Nutrition, 99(S3): S48-S54
Nazki, F.H., Sameer, A.S., Ganaie, B.A. (2014) Folate: Metabolism, genes, polymorphisms and the associated diseases. Gene, 533(1): 11-20
Nikolac, N., Šupak-Smolčić, V., Šimundić, A., Ćelap, I. (2015) Croatian Society of Medical Biochemistry and Laboratory Medicine: National recommendations for venous blood sampling. Biochemia Medica, 25: 242-254
Refsum, H., Smith, A.D., Ueland, P.M., Nexo, E., Clarke, R., Mcpartlin, J., et al. (2004) Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion. Clinical Chemistry, 50(1): 3-32
Seemungal, T.A., Fook, L.C.J., Davis, G., Neblett, C., Chinyepi, N., Dookhan, C., et al. (2007) Plasma homocysteine is elevated in COPD patients and is related to COPD severity. International Journal of Chronic Obstructive Pulmonary Disease, Volume 2: 313-321
Stanojkovic, I., Kotur-Stevuljevic, J., Milenkovic, B., Spasic, S., Vujic, T., Stefanovic, A., Llic, A., Ivanisevic, J. (2011) Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. Respiratory Medicine, 105: Suppl 5: 51-7
Veeranki, S., Tyagi, S.C. (2015) Defective Homocysteine Metabolism: Potential Implications for Skeletal Muscle Malfunction. International Journal of Molecular Sciences, 14(7): 15074-15091
Wald, D.S., Law, M., Morris, J.K. (2002) Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. BMJ, 325(7374): 1202-1206
World Health Organization (WHO)-Vitamin and Mineral Nutrition Information System (2012) Serum and red blood cell folate concentrations for assessing folate status in populations. Geneva, Available at: http://apps.who.int/iris/bitstream/10665/75584/1/WHO_NMH_NHD_EP G_12.1_eng.pdf. Accessed April 10th, 2014
Zappacosta, B., Persichilli, S., Iacoviello, L., di Castelnuovo, A., Graziano, M., Gervasoni, J., Leoncini, E., Cimino, G., Mastroiacovo, P. (2013) Folate, vitamin B12 and homocysteine status in an Italian blood donor population. Nutrition, Metabolism and Cardiovascular Diseases, 23(5): 473-480
 

O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC4922360
DOI: 10.2478/jomb-2014-0046
objavljen u SCIndeksu: 03.01.2020.