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2008, vol. 61, br. 7-8, str. 389-392
Uloga holotranskobalamina u ispitivanju statusa B12 vitamina
aKlinički centar Vojvodine, Centar za laboratorijsku medicinu, Novi Sad
bKlinički centar Vojvodine, Novi Sad

e-adresaveliborcabarkapa@nspoint.net
Ključne reči: Transkobalamini; Vitamin B12; Deficit vitamina B12
Sažetak
Holotranskobalamin sadrži biološki upotrebljiv kobalamin i jedini podstiče ćelijsko preuzimanje kobalamina preko specifičnih receptora. Cilj ove studije bio je da se ispita korisnost određivanja holotranskobalamina u ispitivanju statusa vitamina B12. Ispitivali smo serumski nivo holotranskobalamina kod 135 ispitanika podeljenih u četiri grupe prema serumskim koncentracijama vitamina B12: 30 ispitanika sa vitaminom B12<154 pmol/l, 50 ispitanika sa vitaminom B12 154-250 pmol/l, 30 ispitanika sa vitaminom B12 251-350 pmol/l, 25 ispitanika sa vitaminom B12>350 pmol/l. Rezultati ukazuju da među ispitanicima sa niskim koncentracijama vitamina B12 postoje oni čija je koncentracija holotranskobalamina u granicama referentnih vrednosti. S druge strane, među ispitanicima sa koncentracijama vitamina B12 unutar referentnih vrednosti postoje oni čija je koncentracija holotranskobalamina niska. Između nivoa holotranskobalamina i vitamina B12 postoji pozitivna, statistički značajna korelacija (r=0,62, p<0,001). Zaključujemo da je određivanje nivoa holotranskobalamina korisno u ispitivanju statusa vitamina B12 kako kod osoba sa graničnim vrednostima (154-250 pmol/l), tako i kod onih sa niskim koncentracijama ovog vitamina.
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O članku

jezik rada: srpski
vrsta rada: stručni članak
DOI: 10.2298/MPNS0808389C
objavljen u SCIndeksu: 11.12.2008.

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