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2014, vol. 9, br. 1, str. 31-40
Korelaciona analiza depresivnih ispoljavanja i morfoloških karakteristika moždanih lezija kod bolesnika sa inzultom
aUniverzitet u Banjoj Luci, Medicinski fakultet, Katedra za anatomiju, Republika Srpska, BiH
bKlinički centar Republike Srpske, Klinika za psihijatriju, Banja Luka, Republika Srpska, BiH

e-adresaszlatan@blic.net
Ključne reči: inzult; lezija; depresija; korelacija; analiza
Sažetak
Uvod: Poznavanje etiopatogeneze postinzultnih depresivnih fenomena doprinosi ranoj dijagnostici koja ukoliko je praćena adekvatnom psiho/farmakoterapijom u velikoj meri skraćuje oporavak, i pogoduje socijalnoj i profesionalnoj rehabilitaciji pacijenata. Cilj ovog rada je da se istraži zavisnost pojave depresivnih ispoljavanja od veličine i anatomske lokalizacije lezije. Ispitanici i metode: Istraživanje je obuhvatilo 118 osoba oboljelih od cerebrovaskularnog inzulta. Lokalizacija lezije određivana je na aksijalnimnekontrasnim CT snimcima, a površina i obim lezije primenom AutoCAD digitalne planimetrije. Psihometrijsko ispitivanje pomoću Hamiltonove skale za depresiju izvođeno je metodom slučajnog odabira 11-40 dana nakon inzulta. Korelaciona analiza vršena je prostom linearnom/nelinearnom regresijom, i Coxo-vim hazardnim regresionim modelom. Rezultati: Uočena je negativna korelacija između intenziteta depresivnog ispoljavanja i veličine cerebrovaskularne lezije (Spearman r = - 0.263; P = 0.004). Coxovim regresionim modelom utvrdili smo 4.389 puta veći rizik za pojavu depresije kod osoba ženskog pola, kao i veći rizik usled oštećenja struktura lobus limbicusa (hazard ratio eb (HR) = 2.661, P = 0.019). Zaključak: Manji intenzitet depresivnog ispoljavanja kod većih cerebrovaskularnih lezija objasnili smo aktivacijom reparacionih mehanizama sa uštedom energije i smanjenjem (usled neuroloških ispada) aferentnih perifernih senzacija koje prethode pojavi emocija (James-Langeova periferna teorija emocija).
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.5937/sanamed1401031S
objavljen u SCIndeksu: 06.05.2015.

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