On the basis of many investigations, it has been concluded that the future of agriculture development in the XXI century will imply sustainable agriculture as the alternative to the conventional agriculture. It is considered that the future of agriculture will rest on flexible cultural practices, developments of biotechnology and appreciation of basic ecological principles in soil usage. In intensive field crop production tillage system is of great importance. Tillage system have an effect on many physical, chemical and biological properties of soil. Multiple passes of different agricultural machinery have negative effect on structure, bulk density, total pore space and compaction as well as increased expensive. Today there is need rational solutions for that problems. Conservation tillage practice can increase the organic matter content, aggregate stability, and improve optimal soil water content, air, temperature, biological regime and nutrient cycling that represent basic elements in erosion control, soil and water conservation and environment protection and preservation. The results of our investigation in agroecological condition on experimental fields 'Radmilovac' near Belgrade shows that yield grain of investigated crops (winter wheat, spring barley, maize and soyabean) was lower in mulch tillage system and in no tillage systems than under conventional tillage practice. Reduces in cultural practices can be source of stress (mechanical, drought) and because of that fact plant breeders in the future must attempt to foresee this changes and create new ideotype to existing soil conditions and improving these cultivars in their resource use efficiency. New technologies comprehend higher flexibility of cultural practices (soil tillage, crop rotation, fertilization, integrated pest management) with proper choose of wheat cultivars adapted on these conditions.