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2015, vol. 65, br. 6, str. 329-349
Agmatin u prevenciji akutne neurotoksičnosti izazvane hlorpromazinom kod pacova
aVojnomedicinski centar 'Karaburma', Beograd
bVojnomedicinska akademija, Institut za medicinska istraživanja, Beograd
cUniverzitet u Nišu, Medicinski fakultet, Institut za biohemiju
dUniverzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković'
eInstitut za higijenu i tehnologiju mesa, Beograd

e-adresabracadejanovic@yahoo.com
Projekat:
Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (MPNTR - 41018)
Vojnomedicinska akademija, projekat br. MFVMA/6/15-17

Sažetak
Ova studija se bavi ispitivanjem potencijalno zaštitinih efekata agmatina (AGM) na razvoj oksidativnog/nitrozativnog stresa u selektivno osetljivim strukturama mozga pacova nakon davanja hlorpromazina (HPZ). Sve ispitivane supstance aplikovane su u pojedinačnoj dozi intraperitonealno (i.p.). Životinje su podeljene na kontrolnu (K, 0.9 % fiziološki rastvor), HPZ (HPZ, 38.7 mg/kg TM), HPZ+AGM (AGM, 75 mg/kg TM odmah nakon HPZ, 38.7 mg/kg TM i.p.) i AGM (AGM, 75 mg/kg TM) grupu i žrtvovane dekapitacijom 24 h nakon odgovarajućeg tretmana. Rezultati pokazuju da primena HPZ sa AGM značajno smanjuje koncentraciju leka u mozgu pacova u poređenju sa HPZ-životinjama (p<0.05). Aplikacija HPZ povećava lipidnu peroksidaciju (p<0.001 u korteksu, strijatumu i hipokampusu), koncentraciju nitrita i nitrata (p<0.001 u sva tri ispitivana regiona mozga) i stvaranje superoksidnog anjon radikala (p<0.05 u sve tri moždane strukture) u odnosu na odgovarajuću kontrolu, dok istovremeno utiče na oštećenje enzimskog antioksidativnog sistema (superoksid dizmutaza u korteksu i strijatumu p<0.05, odnosno hipokampusu p<0.001; glutation reduktaza u kori mozga i strijatumu p<0.001, odnosno hipokampusu p<0.05; katalaza u korteksu p<0.001, odnosno strijatumu i hipokampusu p<0.05). Međutim, tretman sa AGM značajno smanjuje parametre oksidativnog stresa u odnosu na HPZ-grupu (lipidna peroksidacija u korteksu p<0.001, strijatumu p<0.01 i hipokampusu p<0.05; koncentracija nitrita i nitrata u sve tri moždane strukture p<0.001) i vraća antioksidativni kapacitet na kontrolne vrednosti u svim ispitivanim moždanim strukturama. Imunohistohemijsko bojenje GFAP molekula kod pacova pokazuje povećanje broja pozitivnih ćelija 24 h nakon akutnog davanja HPZ. Svi prikazani rezultati pokazuju da AGM može biti efikasan u sprečavanju oštećenja mozga izazvanog HPZ kod pacova.
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O članku

jezik rada: srpski
vrsta rada: kratko saopštenje
DOI: 10.5937/arhfarm1506329D
objavljen u SCIndeksu: 24.03.2016.

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