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2015, vol. 34, br. 1, str. 31-37
Metabolički profil i rizici kod gojazne dece
aUniversity Pediatric Clinic, Skopje, Republic of Macedonia
bMedical Faculty, Institute of Medical and Experimental Biochemistry, Skopje, Republic of Macedonia

e-adresamirjanakocova@yahoo.com
Ključne reči: adiponektin; gojaznost; deca; insulinemija; leptin; metabolički profil
Sažetak
Uvod: Epidemija gojaznosti kod dece svih uzrasta u toku poslednjih decenija je plodno polje za istraživanje uzroka i posledica gojaznosti sa glavnim fokusom na uticaju insulinemije i adipocitokina. Metabolička obrada se preporučuje čak i u najmlađoj grupi uzrasta 2-6 godina. Postoje podaci da težina na rođenju može biti faktor pojave i komplikacija gojaznosti kasnije u životu. Metode: Standardnim testovima analizirani su nivoi insulina, leptina i adiponektina kod 269 gojazne i 60 zdrave dece kao i kod 110 novorođenčadi različite težine na rođenju i različite dužine gestacije. Rezultati: Faktori rizika za komplikacije gojaznosti kao sto su dijabetes melitus, gojaznost, hiperlipidemija, infarkt ili cerebralni insult su nađeni kod 53,6% rođaka gojazne dece. Pik insulinemija na OGTT-u je bila značajno viša u pubertetskoj u poređenju sa pretpubertetskom grupom, 110,5±75,9 pU/mL prema 72,2±62,7 pU/mL (p<0,005). Glikozna intolerancija je potvrđena kod 24% ispitanika. Nivo leptina je signifikantno viši kod gojazne dece a adiponektin je niži u poređenju sa pretpubertetskom decom i kontrolnom grupom (p<0,05). Kod novorođenčadi nivoi leptina i adiponektina su u korelaciji sa antropometrijskim parametrima: težinom, visinom, odnosom težina/visina, indeksom telesne mase i ponderalnim indeksom (p<0,05 i <0,01). Zaključak: Gojazna deca imaju visoku vrednost insulina u svim uzrastima i ona dostiže najviše vrednosti u pubertetu. Nivoi leptina i adiponektina mogu biti uključeni u indikatore metaboličkog sindroma. Naši nalazi kod novorođenčadi mogli bi uticati na nutritivni pristup ovoj grupi u budućnosti sa ciljem prevencije komplikacija gojaznosti.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC4922333
DOI: 10.2478/jomb-2014-0065
objavljen u SCIndeksu: 26.12.2019.

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