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2013, vol. 32, br. 1, str. 26-31
Veza između gojaznosti i aktivnosti jetrenih enzima u studentskoj populaciji sa povećanim rizikom za nastanak kardiovaskularnih bolesti
aKlinički centar Srbije, Centar za medicinsku biohemiju, Beograd
bUniverzitet u Novom Sadu, Medicinski fakultet, Institut za zdravstvenu zaštitu dece i omladine
Projekat:
Biomarkeri oštećenja i disfunkcije organa (MPNTR - 175036)

Ključne reči: gojaznost; jetreni enzimi; nealkoholna bolest jetre; kardiovaskularni rizik
Sažetak
Uvod: Poznato je da je gojaznost povezana sa metaboličkim sindromom, insulinskom rezistencijom i kardiovaskularnim rizikom, ali takođe i sa nealkoholnom hroničnom jetrenom bolešću. Prevalenca gojaznosti kod dece i adolescenata je u značajnom porastu svuda u svetu. Cilj ovog rada bio je da se odrede i analiziraju vrednosti jetrenih enzima: aspartat aminotransferaze (AST), alanin aminotransferaze (ALT) i g- glutamil transferaze (gGT) u jednoj grupi gojaznih studenata i da se utvrdi njihova korelacija sa antropometrijskim parametrima: indeksom telesne mase (ITM), obimom struka (OS), obimom kuka (OK) kao i odnosom struk-kuk (OSK). Metode: Dve stotine trideset osam studenata Novosadskog univerziteta je uključeno u ovu studiju; od toga 126 muška­raca i 112 žena, prosečne starosti 22,32 ± 1,85 godina. Na osnovu vrednosti ITM manjeg ili većeg od 25 kg/m2 i OS manjeg ili većeg od 94 cm (za muškarce) tj. 80 cm (za žene), cela grupa studenata podeljena je u dve podgrupe: Grupu 1 (gojazni) - sa povećanim rizikom za nastanak kardiovaskularnih bolesti i Grupu 2 - sa smanjenim rizikom za nastanak istih. Aktivnost enzima AST, ALT i gGT određivana je u uzorcima krvi uzetih natašte. Rezultati: Statističkom obradom podataka utvrđene su statistički značajno veće vrednosti enzima AST, ALT i gGT u grupi studenata sa ITM>25 kg/m2 i OS>94 cm (za muškarce) tj. OS>80 cm (za žene), OK>108 cm (za muškarce) tj. OK>111 cm (za žene) i OSK>0,90 (za muškarce) tj. OSK>0,80 (za žene). Utvrđena je takođe i značajna asocijacija između antropometrijskih parametara i jetrenih enzima(P<0,0001).Zaključak: Na osnovu dobijenih rezultata može se zaključiti da gojazni studenti sa većim vrednostima ITM, OS, OK i OSK imaju i veće vrednosti jetrenih enzima i veću šansu da dobiju nealkoholnu hroničnu bolest jetre (steatozu) u budućnosti.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2478/v10011-012-0024-z
objavljen u SCIndeksu: 02.09.2013.